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Homalomena pineodora essential oil nanoparticle inhibits diabetic wound pathogens.
Rozman, Nur Amiera Syuhada; Tong, Woei Yenn; Leong, Chean Ring; Anuar, Mohd Razealy; Karim, Sabrina; Ong, Siew Kooi; Yusof, Fahmi Asyadi Md; Tan, Wen-Nee; Sulaiman, Baharuddin; Ooi, Mei Lee; Lee, Kok Chang.
Afiliación
  • Rozman NAS; Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Engineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000, Alor Gajah, Melaka, Malaysia.
  • Tong WY; Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Engineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000, Alor Gajah, Melaka, Malaysia. wytong@unikl.edu.my.
  • Leong CR; Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Engineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000, Alor Gajah, Melaka, Malaysia.
  • Anuar MR; Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Engineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000, Alor Gajah, Melaka, Malaysia.
  • Karim S; Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Engineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000, Alor Gajah, Melaka, Malaysia.
  • Ong SK; Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Engineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000, Alor Gajah, Melaka, Malaysia.
  • Yusof FAM; Drug Discovery and Delivery Research Laboratory, Universiti Kuala Lumpur, Malaysian Institute of Chemical and Engineering Technology, Lot 1988 Kawasan Perindustrian Bandar Vendor, Taboh Naning, 78000, Alor Gajah, Melaka, Malaysia.
  • Tan WN; School of Distance Education, Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia.
  • Sulaiman B; School of Biological Sciences, Universiti Sains Malaysia, 11800, Gelugor, Pulau Pinang, Malaysia.
  • Ooi ML; Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat (Perak Campus), 31900, Kampar, Perak, Malaysia.
  • Lee KC; Faculty of Science, Universiti Tunku Abdul Rahman, Jalan Universiti, Bandar Barat (Perak Campus), 31900, Kampar, Perak, Malaysia.
Sci Rep ; 10(1): 3307, 2020 02 24.
Article en En | MEDLINE | ID: mdl-32094395
Essential oil of Homalomena pineodora inhibits diabetic pathogens; however, the activity was not sustainable when applied as wound dressing. This study aims to synthesise the essential oil nanoparticle using chitosan. The nanoparticles were synthesised with ion gelation method, confirmed by spectroscopic analysis. The spherical nanoparticles display a size of 70 nm, with strong surface charge of +24.10 mV. The nanoparticles showed an initial burst release followed by a slow release pattern for 72 h, following the first order of kinetic. The release behaviour was ideal for wound dressing. The antimicrobial activity was broad spectrum. The formation of nanoparticle enhanced the antimicrobial efficacy of the essential oil. The nanoparticle also showed a concentration-dependent killing behaviour on time-kill assay. In the 3D collagen wound models, the nanoparticles reduced the microbial growth by 60-80%. In conclusion, H. pineodora nanoparticles showed pharmaceutical potential in inhibiting microbial growth on diabetic ulcers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Aceites Volátiles / Araceae / Diabetes Mellitus / Nanopartículas Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Aceites Volátiles / Araceae / Diabetes Mellitus / Nanopartículas Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Malasia Pais de publicación: Reino Unido