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Short-Term Prognosis Value of sST2 for an Unfavorable Outcome in Hypertensive Patients.
Farcas, Anca Daniela; Mocan, Mihaela; Anton, Florin Petru; Diana, Mocan-Hognogi Larisa; Chiorescu, Roxana Mihaela; Stoia, Mirela Anca; Vonica, Camelia Larisa; Goidescu, Cerasela Mihaela; Vida-Simiti, Luminița Animarie.
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  • Farcas AD; Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Mocan M; Department of Cardiology, Emergency Clinical County Hospital, Cluj-Napoca, Romania.
  • Anton FP; Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Diana ML; Department of Internal Medicine, Emergency Clinical County Hospital, Cluj-Napoca, Romania.
  • Chiorescu RM; Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Stoia MA; Department of Cardiology, Emergency Clinical County Hospital, Cluj-Napoca, Romania.
  • Vonica CL; Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
  • Goidescu CM; Department of Cardiology, Emergency Clinical County Hospital, Cluj-Napoca, Romania.
  • Vida-Simiti LA; Department of Internal Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Dis Markers ; 2020: 8143737, 2020.
Article en En | MEDLINE | ID: mdl-32089758
BACKGROUND: sST2 represents a useful biomarker for the diagnosis and prognosis of patients with heart failure, but limited data is available on its role in patients with hypertension. The aim of this study is to evaluate the short-term prognosis value of sST2 for an unfavorable outcome in hypertensive patients. METHODS: This was a prospective observational study which enrolled 80 patients with hypertension, who were followed for one year. All patients underwent clinical, laboratory (including sST2), and echocardiographic assessment at baseline. The patients were grouped according to the cardiovascular (CV) events reported during the follow-up: group A (with CV events) and group B (without CV events). RESULTS: Overall, 59 CV events were reported during the follow-up period. Compared to group B, the patients in group A had significantly higher sST2 levels, a higher number of CV risk factors, and a higher left ventricle mass. Except for the diastolic dysfunction parameters, the echocardiographic findings were similar in the two groups. Patients in group A had a lower E/A ratio, larger deceleration time, and increased telediastolic pressure as quantified by the E/E/p = 0.006, Kaplan-Meier analysis). CONCLUSIONS: sST2 levels were correlated with the risk of adverse CV outcomes in hypertensive patients and may represent a useful prognostic marker in these patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Enfermedades Cardiovasculares / Proteína 1 Similar al Receptor de Interleucina-1 / Hipertensión Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Markers Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores / Enfermedades Cardiovasculares / Proteína 1 Similar al Receptor de Interleucina-1 / Hipertensión Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Dis Markers Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Estados Unidos