Your browser doesn't support javascript.
loading
Real-time comprehensive toxicology testing in the clinical management of accidental pediatric capecitabine ingestion.
Gintjee, Thomas J; Goodnough, Robert; Li, Kai; Badea, Adina; Lynch, Kara L; Garcia, Eddie; Repplinger, Daniel.
Afiliación
  • Gintjee TJ; Department of Pharmacy Services, University of California, Davis, CA, USA.
  • Goodnough R; Department of Emergency Medicine, 3989Baylor College of Medicine, Houston, TX, USA.
  • Li K; 6152Kaiser Permanente, Oakland, CA, USA.
  • Badea A; Department of Laboratory Medicine, University of California, San Francisco, CA, USA.
  • Lynch KL; Department of Laboratory Medicine, University of California, San Francisco, CA, USA.
  • Garcia E; Department of Emergency Medicine, University of California, San Francisco, CA, USA.
  • Repplinger D; 209684California Poison Control System San Francisco Division, San Francisco, CA, USA.
J Oncol Pharm Pract ; 26(7): 1759-1761, 2020 Oct.
Article en En | MEDLINE | ID: mdl-32089072
INTRODUCTION: Capecitabine is an orally bioavailable prodrug of the chemotherapeutic agent, fluorouracil. Fluorouracil is converted to several active metabolites that induce a cytotoxic effect. Capecitabine toxicity can be life-threatening with a delayed presentation from ingestion. An oral antidote, uridine triacetate, exists but requires the administration of 20 total doses over a course of five days. CASE REPORT: In this report, we describe a case where timely coordination with a clinical toxicology laboratory was utilized to drive clinical decision making and management. Two children were brought to the emergency department shortly after suspected capecitabine ingestion. MANAGEMENT AND OUTCOME: Patients were admitted to the hospital and started on uridine triacetate. Real-time comprehensive toxicology testing of the children's blood was used to rule out capecitabine toxicity and prevent several unnecessary days of hospitalization and doses of antidote. Patients were discharged safely. DISCUSSION: Real-time comprehensive toxicology testing on a patient's blood may be a valuable resource in ruling out or confirming toxic exposure in accidental pediatric ingestion of chemotherapeutic agents like capecitabine when performed in a timely manner.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uridina / Capecitabina / Acetatos / Antimetabolitos Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Child, preschool / Humans / Male Idioma: En Revista: J Oncol Pharm Pract Asunto de la revista: FARMACIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Uridina / Capecitabina / Acetatos / Antimetabolitos Antineoplásicos Tipo de estudio: Prognostic_studies Límite: Child, preschool / Humans / Male Idioma: En Revista: J Oncol Pharm Pract Asunto de la revista: FARMACIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido