Your browser doesn't support javascript.
loading
Stability study of thymoquinone, carvacrol and thymol using HPLC-UV and LC-ESI-MS.
Soliman, Rabab M; Abdel Salam, Randa A; Eid, Basma G; Khayyat, Ahdab; Neamatallah, Thikryat; Mesbah, Mostafa K; Hadad, Ghada M.
Afiliación
  • Soliman RM; Department of Pharmaceutical Chemistry Faculty of Pharmacy, Sinai University El Arish, North Sinai, Egypt.
  • Abdel Salam RA; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
  • Eid BG; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Khayyat A; Pharmaceutical Chemistry Department Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Neamatallah T; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.
  • Mesbah MK; Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, IsmailiaEgypt.
  • Hadad GM; Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Acta Pharm ; 70(3): 325-342, 2020 Sep 01.
Article en En | MEDLINE | ID: mdl-32074066
The aim of this study was to investigate the stability of three major antioxidants of Nigella sativa: thymoquinone (TQ), carvacrol (CR) and thymol (THY), under different stress conditions using HPLC and LC-MS/MS. Forced degradation for each compound was performed under different conditions, including oxidation, hydrolysis, photolysis and thermal decomposition. The results showed that both CR and THY were stable under the studied conditions, whereas TQ was not affected by acidic, basic and oxidative forced conditions but the effect of light and heat was significant. The degradation products of TQ were further investigated and characterized by LC-MS/MS. HPLC-UV method has been fully validated in terms of linearity and range, the limit of detection and quantitation, precision, selectivity, accuracy and robustness. The method was successfully applied to quantitative analysis of the principal antioxidants of Nigella sativa TQ, CR and THY in different phytopharmaceuticals.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timol / Benzoquinonas / Cimenos / Antioxidantes Idioma: En Revista: Acta Pharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Polonia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Timol / Benzoquinonas / Cimenos / Antioxidantes Idioma: En Revista: Acta Pharm Asunto de la revista: FARMACIA / FARMACOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Polonia