Cultivation of exoerythrocytic stages of Plasmodium cynomolgi, P. knowlesi, P. coatneyi, and P. inui in Macaca mulatta hepatocytes.

Millet, P; Fisk, T L; Collins, W E; Broderson, J R; Nguyen-Dinh, P

Millet, P; Fisk, T L; Collins, W E; Broderson, J R; Nguyen-Dinh, P.

Afiliación

Millet P; Malaria Branch, Center for Infectious Diseases, U.S. Department of Health and Human Services, Atlanta, Georgia 30333.

Am J Trop Med Hyg ; 39(6): 529-34, 1988 Dec.

Article en En | MEDLINE | ID: mdl-3207173

RESUMEN

Exoerythrocytic stage parasites of Plasmodium cynomolgi, P. knowlesi, P. coatneyi, and P. inui were cultured by inoculating primary cultures of hepatocytes from Macaca mulatta with sporozoites. Less than 1% of inoculated sporozoites survived. Morphology and size of the liver stages in all 4 species were similar to in vivo descriptions and the time required for in vitro maturation correlated well with prepatent periods described.

Asunto(s)

Hígado/parasitología; Plasmodium/crecimiento & desarrollo; Animales; Células Cultivadas; Hígado/citología; Macaca mulatta

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plasmodium / Hígado Límite: Animals Idioma: En Revista: Am J Trop Med Hyg Año: 1988 Tipo del documento: Article Pais de publicación: Estados Unidos

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