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Mechano-biological adaptation of the pulmonary artery exposed to systemic conditions.
Vanderveken, Emma; Vastmans, Julie; Claus, Piet; Verbeken, Eric; Fehervary, Heleen; Van Hoof, Lucas; Vandendriessche, Katrien; Verbrugghe, Peter; Famaey, Nele; Rega, Filip.
Afiliación
  • Vanderveken E; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium. emma.vanderveken@kuleuven.be.
  • Vastmans J; Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.
  • Claus P; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
  • Verbeken E; Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.
  • Fehervary H; Department of Mechanical Engineering, KU Leuven, Leuven, Belgium.
  • Van Hoof L; Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
  • Vandendriessche K; Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
  • Verbrugghe P; Department of Cardiac Surgery, University Hospitals Leuven, Leuven, Belgium.
  • Famaey N; Department of Mechanical Engineering, KU Leuven, Leuven, Belgium. nele.famaey@kuleuven.be.
  • Rega F; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
Sci Rep ; 10(1): 2724, 2020 02 17.
Article en En | MEDLINE | ID: mdl-32066803
Cardiac surgeries may expose pulmonary arterial tissue to systemic conditions, potentially resulting in failure of that tissue. Our goal was to quantitatively assess pulmonary artery adaptation due to changes in mechanical environment. In 17 sheep, we placed a pulmonary autograft in aortic position, with or without macroporous mesh reinforcement. It was exposed to systemic conditions for 6 months. All sheep underwent 3 ECG-gated MRI's. Explanted tissue was subjected to mechanical and histological analysis. Results showed progressive dilatation of the unreinforced autograft, while reinforced autografts stabilized after two months. Some unreinforced pulmonary autograft samples displayed more aorta-like mechanical behavior with increased collagen deposition. The mechanical behavior of reinforced autografts was dominated by the mesh. The decrease in media thickness and loss of vascular smooth muscle cells was more pronounced in reinforced than in unreinforced autografts. In conclusion, altering the mechanical environment of a pulmonary artery causes changes in its mechano-biological properties.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta / Arteria Pulmonar / Adaptación Fisiológica / Autoinjertos / Procedimientos Quirúrgicos Cardíacos Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aorta / Arteria Pulmonar / Adaptación Fisiológica / Autoinjertos / Procedimientos Quirúrgicos Cardíacos Límite: Animals Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Reino Unido