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Reductive Stress, Bioactive Compounds, Redox-Active Metals, and Dormant Tumor Cell Biology to Develop Redox-Based Tools for the Treatment of Cancer.
Quiles, José L; Sánchez-González, Cristina; Vera-Ramírez, Laura; Giampieri, Francesca; Navarro-Hortal, M Dolores; Xiao, Jianbo; Llopis, Juan; Battino, Maurizio; Varela-López, Alfonso.
Afiliación
  • Quiles JL; Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Center, University of Granada, Granada, Spain.
  • Sánchez-González C; College of Food Science and Technology, Northwest University, Xi'an, China.
  • Vera-Ramírez L; Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Center, University of Granada, Granada, Spain.
  • Giampieri F; Department of Genomic Medicine, GENYO: Centre for Genomics and Oncology (Pfizer-University of Granada and Andalusian Regional Government), Granada, Spain.
  • Navarro-Hortal MD; College of Food Science and Technology, Northwest University, Xi'an, China.
  • Xiao J; Department of Clinical Sciences, Università Politecnica delle Marche, Ancona, Italy.
  • Llopis J; Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Center, University of Granada, Granada, Spain.
  • Battino M; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang, China.
  • Varela-López A; Department of Physiology, Institute of Nutrition and Food Technology "José Mataix Verdú", Biomedical Research Center, University of Granada, Granada, Spain.
Antioxid Redox Signal ; 33(12): 860-881, 2020 10 20.
Article en En | MEDLINE | ID: mdl-32064905
Significance: Cancer is related to redox biology from many points of view, such as initiation and promotion, metabolism and growth, invasion and metastasis, vascularization, or through the interaction with the immune system. In addition, this extremely complex relationship depends on the redox homeostasis of each cellular compartment, which might be used to fight cancer. Recent Advances: New ways of modulating specific and little explored aspects of redox biology have been revealed, as well as new delivery methods or uses of previously known treatments against cancer. Here, we review the latest experimental evidence regarding redox biology in cancer treatment and analyze its potential impact in the development of improved and more effective antineoplastic therapies. Critical Issues: A critical issue that deserves particular attention is the understanding that both extremes of redox biology (i.e., oxidative stress [OS] and reductive stress) might be useful or harmful in relation to cancer prevention and treatment. Future Directions: Additional research is needed to understand how to selectively induce reductive or OS adequately to avoid cancer proliferation or to induce cancer cell death.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Productos Biológicos / Estrés Oxidativo / Metales / Neoplasias Límite: Animals / Humans Idioma: En Revista: Antioxid Redox Signal Asunto de la revista: METABOLISMO Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Oxidación-Reducción / Productos Biológicos / Estrés Oxidativo / Metales / Neoplasias Límite: Animals / Humans Idioma: En Revista: Antioxid Redox Signal Asunto de la revista: METABOLISMO Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Estados Unidos