The antiarrhythmic compound efsevin directly modulates voltage-dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca<sup>2+</sup> uptake.

Wilting, Fabiola; Kopp, Robin; Gurnev, Philip A; Schedel, Anna; Dupper, Nathan J; Kwon, Ohyun; Nicke, Annette; Gudermann, Thomas; Schredelseker, Johann

The antiarrhythmic compound efsevin directly modulates voltage-dependent anion channel 2 by binding to its inner wall and enhancing mitochondrial Ca²⁺ uptake.

Wilting, Fabiola; Kopp, Robin; Gurnev, Philip A; Schedel, Anna; Dupper, Nathan J; Kwon, Ohyun; Nicke, Annette; Gudermann, Thomas; Schredelseker, Johann.

Afiliación

Wilting F; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.
Kopp R; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.
Gurnev PA; Section on Molecular Transport, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Schedel A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.
Dupper NJ; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California.
Kwon O; Department of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, California.
Nicke A; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.
Gudermann T; Walther Straub Institute of Pharmacology and Toxicology, Faculty of Medicine, LMU Munich, Munich, Germany.
Schredelseker J; Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Partner Site Munich Heart Alliance (MHA), Munich, Germany.

Br J Pharmacol ; 177(13): 2947-2958, 2020 07.

Article en En | MEDLINE | ID: mdl-32059260

Asunto(s)

Calcio/metabolismo; Mitocondrias; Canal Aniónico 2 Dependiente del Voltaje; Animales; Transporte Biológico; Mitocondrias/metabolismo; Membranas Mitocondriales/metabolismo; Miocitos Cardíacos/metabolismo; Canal Aniónico 2 Dependiente del Voltaje/agonistas; Canal Aniónico 2 Dependiente del Voltaje/metabolismo; Pez Cebra; Proteínas de Pez Cebra

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Calcio / Canal Aniónico 2 Dependiente del Voltaje / Mitocondrias Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Br J Pharmacol Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido

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