Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism.
Nanomaterials (Basel)
; 10(2)2020 Feb 10.
Article
en En
| MEDLINE
| ID: mdl-32050630
Biodegradable polymers hold great therapeutic value, especially through the addition of additives for controlled drug release. Nanocellulose has shown promise in drug delivery, yet usually requires chemical crosslinking with harsh acids and solvents. Nanocellulose fibrils (NFCs) and 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO)-mediated oxidized nanocellulose fibrils (TNFCs) with poly (vinyl alcohol) (PVA) could be aqueously formulated to control the release of model drug acetaminophen over 144 hours. The release was evaluated with a multiphase release mechanism to determine which mechanism(s) contribute to the overall release and to what degree. Doing so indicated that the TNFCs in PVA control the release of acetaminophen more than NFCs in PVA. Modeling showed that this release was mostly due to burst release-drug coming off the immediate surface, rather than diffusing out of the matrix.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Nanomaterials (Basel)
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Suiza