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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Oshima, Nobu; Ishida, Ryo; Kishimoto, Shun; Beebe, Kristin; Brender, Jeffrey R; Yamamoto, Kazutoshi; Urban, Daniel; Rai, Ganesha; Johnson, Michelle S; Benavides, Gloria; Squadrito, Giuseppe L; Crooks, Dan; Jackson, Joseph; Joshi, Abhinav; Mott, Bryan T; Shrimp, Jonathan H; Moses, Michael A; Lee, Min-Jung; Yuno, Akira; Lee, Tobie D; Hu, Xin; Anderson, Tamara; Kusewitt, Donna; Hathaway, Helen H; Jadhav, Ajit; Picard, Didier; Trepel, Jane B; Mitchell, James B; Stott, Gordon M; Moore, William; Simeonov, Anton; Sklar, Larry A; Norenberg, Jeffrey P; Linehan, W Marston; Maloney, David J; Dang, Chi V; Waterson, Alex G; Hall, Matthew; Darley-Usmar, Victor M; Krishna, Murali C; Neckers, Leonard M.
Afiliación
  • Oshima N; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Ishida R; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Kishimoto S; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Beebe K; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Brender JR; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Yamamoto K; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Urban D; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Rai G; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Johnson MS; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Benavides G; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Squadrito GL; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Crooks D; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Jackson J; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Joshi A; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland.
  • Mott BT; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Shrimp JH; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Moses MA; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Lee MJ; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Yuno A; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Lee TD; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Hu X; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Anderson T; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Kusewitt D; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Hathaway HH; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Jadhav A; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Picard D; Department of Cell Biology, University of Geneva, 1211 Geneva 4, Switzerland.
  • Trepel JB; Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Mitchell JB; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Stott GM; Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD 24060, USA.
  • Moore W; Leidos Biomedical, Frederick National Laboratory for Cancer Research, Frederick, MD 24060, USA.
  • Simeonov A; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Sklar LA; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Norenberg JP; University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.
  • Linehan WM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Maloney DJ; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Dang CV; Ludwig Institute for Cancer Research, New York, NY 10017, USA; The Wistar Institute, Philadelphia, PA 19104, USA.
  • Waterson AG; Department of Chemistry, Vanderbilt University, Nashville, TN 37240, USA.
  • Hall M; Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.
  • Darley-Usmar VM; Mitochondrial Medicine Laboratory, Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Krishna MC; Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA.
  • Neckers LM; Urologic Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD 20892, USA. Electronic address: neckersl@mail.nih.gov.
Cell Rep ; 30(6): 1798-1810.e4, 2020 02 11.
Article en En | MEDLINE | ID: mdl-32049011
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimioterapia Combinada / L-Lactato Deshidrogenasa / Neoplasias Límite: Animals / Humans Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quimioterapia Combinada / L-Lactato Deshidrogenasa / Neoplasias Límite: Animals / Humans Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos