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Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study.
His, Mathilde; Biessy, Carine; Torres-Mejía, Gabriela; Ángeles-Llerenas, Angélica; Alvarado-Cabrero, Isabel; Sánchez, Gloria Inés; Borrero, Mauricio; Porras, Carolina; Rodriguez, Ana Cecilia; Garmendia, Maria Luisa; Olivier, Magali; Porter, Peggy L; Lin, MingGang; Gunter, Marc J; Romieu, Isabelle; Rinaldi, Sabina.
Afiliación
  • His M; Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
  • Biessy C; Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
  • Torres-Mejía G; Centre for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico.
  • Ángeles-Llerenas A; Centre for Population Health Research, National Institute of Public Health, Cuernavaca, Mexico.
  • Alvarado-Cabrero I; Servicio de Patología del Hospital de Oncología, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico city, Mexico.
  • Sánchez GI; Group Infection and Cancer, School of Medicine, University of Antioquia, Medellín, Colombia.
  • Borrero M; Group Infection and Cancer, School of Medicine, University of Antioquia, Medellín, Colombia.
  • Porras C; Department of Gynecology and Obstetrics, School of Medicine, University or Antioquia, Medellín, Colombia.
  • Rodriguez AC; Cinica Vida Fundacion, Medellín, Colombia.
  • Garmendia ML; Agencia Costarricense de Investigaciones Biomédicas (ACIB)-Fundación INCIENSA, San José, Costa Rica.
  • Olivier M; Agencia Costarricense de Investigaciones Biomédicas (ACIB)-Fundación INCIENSA, San José, Costa Rica.
  • Porter PL; Instituto de Nutrición y de Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile.
  • Lin M; Molecular Mechanisms and Biomarkers Group, Section of Mechanisms of Carcinogenesis, International Agency for Research on Cancer, Lyon, France.
  • Gunter MJ; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States of America.
  • Romieu I; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States of America.
  • Rinaldi S; Section of Nutrition and Metabolism, International Agency for Research on Cancer, Lyon, France.
Sci Rep ; 10(1): 2294, 2020 02 10.
Article en En | MEDLINE | ID: mdl-32042008
Cumulating evidence in Caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20-45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m2 = 0.93; 95% confidence interval = 0.89-0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69-0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67-0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMI < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47-8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98-1.94)). Body shape at younger ages and body shape evolution were not associated with risk. No heterogeneity was observed by receptor status. In this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Premenopausia / Adiposidad / Circunferencia de la Cintura / Obesidad Abdominal Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Premenopausia / Adiposidad / Circunferencia de la Cintura / Obesidad Abdominal Tipo de estudio: Clinical_trials / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Sci Rep Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Reino Unido