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Capsaicin Exerts Anti-convulsant and Neuroprotective Effects in Pentylenetetrazole-Induced Seizures.
Abdel-Salam, Omar M E; Sleem, Amany A; Sayed, Marawan Abd El Baset Mohamed; Youness, Eman R; Shaffie, Nermeen.
Afiliación
  • Abdel-Salam OME; Department of Toxicology and Narcotics, National Research Centre, Tahrir Street, Dokki, Cairo, Egypt. omasalam@hotmail.com.
  • Sleem AA; Department of Pharmacology, Tahrir Street, Dokki, Cairo, Egypt.
  • Sayed MAEBM; Department of Pharmacology, Tahrir Street, Dokki, Cairo, Egypt.
  • Youness ER; Department of Medical Biochemistry, Tahrir Street, Dokki, Cairo, Egypt.
  • Shaffie N; Department of Pathology, National Research Centre, Tahrir Street, Dokki, Cairo, Egypt.
Neurochem Res ; 45(5): 1045-1061, 2020 May.
Article en En | MEDLINE | ID: mdl-32036609
The transient receptor potential vanilloid-1 (TRPV1) receptor has been implicated in the development of epileptic seizures. We examined the effect of the TRPV1 agonist capsaicin on epileptic seizures, neuronal injury and oxidative stress in a model of status epilepticus induced in the rat by intraperitoneal (i.p.) injections of pentylenetetrazole (PTZ). Capsaicin was i.p. given at 1 or 2 mg/kg, 30 min before the first PTZ injection. Other groups were i.p. treated with the vehicle or the anti-epileptic drug phenytoin (30 mg/kg) alone or co-administered with capsaicin at 2 mg/kg. Brain levels of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide, and paraoxonase-1 (PON-1) activity, seizure scores, latency time and PTZ dose required to reach status epilepticus were determined. Histopathological assessment of neuronal damage was done. Results showed that brain MDA decreased by treatment with capsaicin, phenytoin or capsaicin/phenytoin. Nitric oxide decreased by capsaicin or capsaicin/phenytoin. GSH and PON-1 activity increased after capsaicin, phenytoin or capsaicin/phenytoin. Mean total seizure score decreased by 48.8% and 66.3% by capsaicin compared with 78.7% for phenytoin and 69.8% for capsaicin/phenytoin treatment. Only phenytoin increased the latency (115.7%) and threshold dose of PTZ (78.3%). Capsaicin did not decrease the anti-convulsive effect of phenytoin but prevented the phenytoin-induced increase in latency time and threshold dose. Neuronal damage decreased by phenytoin or capsaicin at 2 mg/kg but almost completely prevented by capsaicin/phenytoin. Thus in this model of status epilepticus, capsaicin decreased brain oxidative stress, the severity of seizures and neuronal injury and its co-administration with phenytoin afforded neuronal protection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pentilenotetrazol / Convulsiones / Capsaicina / Fármacos Neuroprotectores / Anticonvulsivantes Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurochem Res Año: 2020 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pentilenotetrazol / Convulsiones / Capsaicina / Fármacos Neuroprotectores / Anticonvulsivantes Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Neurochem Res Año: 2020 Tipo del documento: Article País de afiliación: Egipto Pais de publicación: Estados Unidos