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Characteristics of youth at high risk for bipolar disorder compared to youth with bipolar I or II disorder.
Weintraub, Marc J; Schneck, Christopher D; Walshaw, Patricia D; Chang, Kiki D; Singh, Manpreet K; Axelson, David A; Birmaher, Boris; Miklowitz, David J.
Afiliación
  • Weintraub MJ; UCLA Semel Institute, University of California, Los Angeles, CA, USA. Electronic address: mjweintraub@mednet.ucla.edu.
  • Schneck CD; Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Walshaw PD; UCLA Semel Institute, University of California, Los Angeles, CA, USA.
  • Chang KD; Private Practice, Menlo Park, CA, USA.
  • Singh MK; Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA.
  • Axelson DA; Department of Psychiatry, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA.
  • Birmaher B; Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  • Miklowitz DJ; UCLA Semel Institute, University of California, Los Angeles, CA, USA.
J Psychiatr Res ; 123: 48-53, 2020 04.
Article en En | MEDLINE | ID: mdl-32036073
Significant efforts have been undertaken to characterize the phenomenology of the high-risk period for bipolar disorder (BD) through the examination of youth at familial risk (i.e., having a first- or second-degree relative with BD) or clinical high risk for the disorder (i.e., youth with BD Not Otherwise Specified [NOS] or major depressive disorder [MDD]). However, little is known about the phenomenology of youth at both familial and clinical high risk for BD. In this study, we examined the clinical and psychosocial characteristics of youth at familial and clinical high risk (HR) for BD, and compared these characteristics to those of youth with BD I and II. Both groups were recruited based on current, active mood symptoms from separate randomized trials of family therapy. A total of 127 HR youth were evaluated: 52 (40.9%) were diagnosed with BD-NOS and 75 (59.1%) were diagnosed with MDD. Compared to adolescents with BD I and II (n = 145), HR youth had higher rates of anxiety disorders, and comparable rates of attention-deficit/hyperactivity disorder and oppositional defiant disorder/conduct disorder. Manic symptom severity and psychosocial functioning were progressively more impaired consistent with diagnostic severity: BD I > BD II > BD-NOS > MDD. Nonetheless, HR youth exhibited depressive symptom severity that was comparable to adolescents with BD I. These results provide further support for the high rates of anxiety disorders and premorbid dysfunction in addition to active mood symptoms for youth at risk for BD, and suggest anxiety is an important phenomenological characteristic and treatment target in the high-risk period.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Trastorno Bipolar / Trastorno Depresivo Mayor Tipo de estudio: Clinical_trials / Etiology_studies / Qualitative_research / Risk_factors_studies Límite: Adolescent / Humans Idioma: En Revista: J Psychiatr Res Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Trastorno Bipolar / Trastorno Depresivo Mayor Tipo de estudio: Clinical_trials / Etiology_studies / Qualitative_research / Risk_factors_studies Límite: Adolescent / Humans Idioma: En Revista: J Psychiatr Res Año: 2020 Tipo del documento: Article Pais de publicación: Reino Unido