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Management of chronic wasting disease in ranched elk: conclusions from a longitudinal three-year study.
Haley, N J; Henderson, D M; Donner, R; Wyckoff, S; Merrett, K; Tennant, J; Hoover, E A; Love, D; Kline, E; Lehmkuhl, A D; Thomsen, B V.
Afiliación
  • Haley NJ; Department of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.
  • Henderson DM; Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
  • Donner R; Department of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.
  • Wyckoff S; Department of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.
  • Merrett K; Department of Microbiology and Immunology, College of Graduate Studies, Midwestern University, Glendale, AZ, USA.
  • Tennant J; Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
  • Hoover EA; Prion Research Center, Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA.
  • Love D; Colorado Department of Agriculture Animal Health Division, Broomfield, CO, USA.
  • Kline E; Colorado Department of Agriculture Animal Health Division, Broomfield, CO, USA.
  • Lehmkuhl AD; National Veterinary Services Laboratories, United States Department of Agriculture, APHIS, VS, Ames, IA, USA.
  • Thomsen BV; National Veterinary Services Laboratories, United States Department of Agriculture, APHIS, VS, Ames, IA, USA.
Prion ; 14(1): 76-87, 2020 12.
Article en En | MEDLINE | ID: mdl-32033521
Chronic wasting disease is a fatal, horizontally transmissible prion disease of cervid species that has been reported in free-ranging and farmed animals in North America, Scandinavia, and Korea. Like other prion diseases, CWD susceptibility is partly dependent on the sequence of the prion protein encoded by the host's PRNP gene; it is unknown if variations in PRNP have any meaningful effects on other aspects of health. Conventional diagnosis of CWD relies on ELISA or IHC testing of samples collected post-mortem, with recent efforts focused on antemortem testing approaches. We report on the conclusions of a study evaluating the role of antemortem testing of rectal biopsies collected from over 570 elk in a privately managed herd, and the results of both an amplification assay (RT-QuIC) and conventional IHC among animals with a several PRNP genotypes. Links between PRNP genotype and potential markers of evolutionary fitness, including pregnancy rates, body condition, and annual return rates were also examined. We found that the RT-QuIC assay identified significantly more CWD positive animals than conventional IHC across the course of the study, and was less affected by factors known to influence IHC sensitivity - including follicle count and PRNP genotype. We also found that several evolutionary markers of fitness were not adversely correlated with specific PRNP genotypes. While the financial burden of the disease in this herd was ultimately unsustainable for the herd owners, our scientific findings and the hurdles encountered will assist future CWD management strategies in both wild and farmed elk and deer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ciervos / Enfermedad Debilitante Crónica Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Prion Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ciervos / Enfermedad Debilitante Crónica Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Animals / Pregnancy País/Región como asunto: America do norte Idioma: En Revista: Prion Asunto de la revista: BIOQUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos