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Phasic and tonic serotonin modulate alarm reactions and post-exposure behavior in zebrafish.
Lima-Maximino, Monica; Pyterson, Maryana Pereira; do Carmo Silva, Rhayra Xavier; Gomes, Gabriela Cristini Vidal; Rocha, Sueslene Prado; Herculano, Anderson Manoel; Rosemberg, Denis Broock; Maximino, Caio.
Afiliación
  • Lima-Maximino M; Laboratório de Neurofarmacologia e Biofísica, Centro de Ciências Biológicas e da Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Marabá, Brazil.
  • Pyterson MP; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff", Faculdade de Psicologia, Universidade Federal do Sul e Sudeste do Pará, Marabá, Brazil.
  • do Carmo Silva RX; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff", Faculdade de Psicologia, Universidade Federal do Sul e Sudeste do Pará, Marabá, Brazil.
  • Gomes GCV; Programa de Pós-Graduação em Neurociências e Biologia Celular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Brazil.
  • Rocha SP; Laboratório de Neurociências e Comportamento "Frederico Guilherme Graeff", Faculdade de Psicologia, Universidade Federal do Sul e Sudeste do Pará, Marabá, Brazil.
  • Herculano AM; Laboratório de Neurofarmacologia e Biofísica, Centro de Ciências Biológicas e da Saúde, Departamento de Morfologia e Ciências Fisiológicas, Universidade do Estado do Pará, Marabá, Brazil.
  • Rosemberg DB; Laboratório de Neurofarmacologia Experimental, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, Brazil.
  • Maximino C; Laboratório de Neuropsicobiologia Experimental, Departamento de Bioquímica e Biologia Molecular, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, Brazil.
J Neurochem ; 153(4): 495-509, 2020 05.
Article en En | MEDLINE | ID: mdl-32031241
Current theories on the role of serotonin (5-HT) in vertebrate defensive behavior suggest that this monoamine increases anxiety but decreases fear, by acting at different levels of the neuroaxis. This paradoxical, dual role of 5-HT suggests that a serotonergic tone inhibits fear responses, while an acute increase in 5-HT would produce anxiety-like behavior. However, so far no evidence for a serotonergic tone has been found. Using zebrafish alarm responses, we investigate the participation of phasic and tonic 5-HT levels in fear-like behavior, as well as in behavior after stimulation. Conspecific alarm substance (CAS) increased bottom-dwelling and erratic swimming, and animals transferred to a novel environment after CAS exposure (post-exposure behavior) showed increased bottom-dwelling and freezing. Clonazepam blocked CAS effects during and after exposure. Acute fluoxetine dose-dependently decreased fear-like behavior, but increased post-exposure freezing. Metergoline had no effect on fear-like behavior, but blocked the effects of CAS on post-exposure behavior; similar effects were observed with para-chlorophenylalanine. Finally, CAS was shown to decrease the activity of monoamine oxidase in the zebrafish brain after exposure. These results suggest that phasic and tonic serotonin encode an aversive expectation value, switching behavior toward cautious exploration/risk assessment/anxiety when the aversive stimulus is no longer present.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serotonina / Inhibidores Selectivos de la Recaptación de Serotonina / Conducta Exploratoria / Miedo Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: J Neurochem Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serotonina / Inhibidores Selectivos de la Recaptación de Serotonina / Conducta Exploratoria / Miedo Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: J Neurochem Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido