Exosomal Sonic Hedgehog derived from cancer-associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma.

Zhao, Guiping; Li, Hengcun; Guo, Qingdong; Zhou, Anni; Wang, Xingyu; Li, Peng; Zhang, Shutian

Zhao, Guiping; Li, Hengcun; Guo, Qingdong; Zhou, Anni; Wang, Xingyu; Li, Peng; Zhang, Shutian.

Afiliación

Zhao G; Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China.
Li H; Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China.
Guo Q; Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China.
Zhou A; Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China.
Wang X; Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China.
Li P; Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China.
Zhang S; Department of Gastroenterology, National Clinical Research Center for Digestive Disease, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Beijing Friendship Hospital, Capital Medical University, Beijing, P. R. China.

Cancer Med ; 9(7): 2500-2513, 2020 04.

Article en En | MEDLINE | ID: mdl-32030915

Asunto(s)

Biomarcadores de Tumor/metabolismo; Fibroblastos Asociados al Cáncer/patología; Movimiento Celular; Proliferación Celular; Carcinoma de Células Escamosas de Esófago/patología; Exosomas/metabolismo; Proteínas Hedgehog/metabolismo; Animales; Apoptosis; Biomarcadores de Tumor/genética; Fibroblastos Asociados al Cáncer/metabolismo; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/metabolismo; Neoplasias Esofágicas/patología; Carcinoma de Células Escamosas de Esófago/genética; Carcinoma de Células Escamosas de Esófago/metabolismo; Exosomas/genética; Regulación Neoplásica de la Expresión Génica; Proteínas Hedgehog/genética; Humanos; Masculino; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Transducción de Señal; Células Tumorales Cultivadas; Ensayos Antitumor por Modelo de Xenoinjerto

Palabras clave

Sonic Hedgehog; cancer-associated fibroblasts; esophageal squamous cell carcinoma; exosomes

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Biomarcadores de Tumor / Movimiento Celular / Proliferación Celular / Proteínas Hedgehog / Exosomas / Fibroblastos Asociados al Cáncer / Carcinoma de Células Escamosas de Esófago Tipo de estudio: Risk_factors_studies Límite: Animals / Humans / Male Idioma: En Revista: Cancer Med Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos

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