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Appendix Tumor Microenvironment.
Roncati, Luca; Gasparri, Paolo; Gallo, Graziana; Bernardelli, Giuditta; Zanelli, Giuliana; Manenti, Antonio.
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  • Roncati L; Department of Medical and Surgical Sciences, Institute of Pathology, University Hospital of Modena, Modena (MO), Italy.
  • Gasparri P; Department of Medical and Surgical Sciences, Institute of Pathology, University Hospital of Modena, Modena (MO), Italy.
  • Gallo G; Department of Medical and Surgical Sciences, Institute of Pathology, University Hospital of Modena, Modena (MO), Italy.
  • Bernardelli G; Department of Medical and Surgical Sciences, Institute of Pathology, University Hospital of Modena, Modena (MO), Italy.
  • Zanelli G; Department of Medical and Surgical Sciences, Institute of Pathology, University Hospital of Modena, Modena (MO), Italy.
  • Manenti A; Department of Medical and Surgical Sciences, Section of Surgery, University Hospital of Modena, Modena (MO), Italy.
Adv Exp Med Biol ; 1226: 87-95, 2020.
Article en En | MEDLINE | ID: mdl-32030678
The pathological features of the appendix tumors fundamentally recall those of the more frequent colorectal neoplasms, although with a higher relative incidence of carcinoids, due to the abundant presence of enteroendocrine cells in the appendix wall. Moreover, different types of lymphomas, Hodgkin and non-Hodgkin, arising from the extra-nodal mucosal-associated lymphatic tissue, can be encountered. The appendix tumor microenvironment (TME) consists of a cellular component and of a noncellular component: the former includes the immunocompetent cells, while the latter represents the support stroma. Particularly in carcinoids, the immune cell reaction can be explicated by tumor-infiltrating lymphocytes, which, in some circumstances, may arrange around and inside the tumor in a brisk fashion influencing favorably the prognosis. This active reaction has to be distinguished from any preexisting inflammatory condition of the appendix and from superimposed tumor complications, such as infection or ischemia. In practice, we consider the appendix TME a complex framework with immunological, mechanic, and metabolic functions, all supported by a marked neo-lymphoangiogenesis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Apéndice / Microambiente Tumoral Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Adv Exp Med Biol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias del Apéndice / Microambiente Tumoral Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Adv Exp Med Biol Año: 2020 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Estados Unidos