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The landscape of viral associations in human cancers.
Zapatka, Marc; Borozan, Ivan; Brewer, Daniel S; Iskar, Murat; Grundhoff, Adam; Alawi, Malik; Desai, Nikita; Sültmann, Holger; Moch, Holger; Cooper, Colin S; Eils, Roland; Ferretti, Vincent; Lichter, Peter.
Afiliación
  • Zapatka M; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Borozan I; Informatics and Bio-computing Program, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
  • Brewer DS; Norwich Medical School, University of East Anglia, Norwich, UK.
  • Iskar M; Earlham Institute, Norwich, UK.
  • Grundhoff A; Division of Molecular Genetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Alawi M; Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Desai N; German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck-Riems, Hamburg, Germany.
  • Sültmann H; Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany.
  • Moch H; Bioinformatics Core, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Cooper CS; Biomedical Data Science Laboratory, Francis Crick Institute, London, UK.
  • Eils R; National Center for Tumor Diseases (NCT) Heidelberg, Heidelberg, Germany.
  • Ferretti V; Division of Cancer Genome Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Lichter P; German Cancer Consortium (DKTK), Heidelberg, Germany.
Nat Genet ; 52(3): 320-330, 2020 03.
Article en En | MEDLINE | ID: mdl-32025001
Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, for which whole-genome and-for a subset-whole-transcriptome sequencing data from 2,658 cancers across 38 tumor types was aggregated, we systematically investigated potential viral pathogens using a consensus approach that integrated three independent pipelines. Viruses were detected in 382 genome and 68 transcriptome datasets. We found a high prevalence of known tumor-associated viruses such as Epstein-Barr virus (EBV), hepatitis B virus (HBV) and human papilloma virus (HPV; for example, HPV16 or HPV18). The study revealed significant exclusivity of HPV and driver mutations in head-and-neck cancer and the association of HPV with APOBEC mutational signatures, which suggests that impaired antiviral defense is a driving force in cervical, bladder and head-and-neck carcinoma. For HBV, HPV16, HPV18 and adeno-associated virus-2 (AAV2), viral integration was associated with local variations in genomic copy numbers. Integrations at the TERT promoter were associated with high telomerase expression evidently activating this tumor-driving process. High levels of endogenous retrovirus (ERV1) expression were linked to a worse survival outcome in patients with kidney cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Tumorales por Virus / Genoma Humano / Integración Viral / Virus ADN Tumorales / Transcriptoma / Neoplasias Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Tumorales por Virus / Genoma Humano / Integración Viral / Virus ADN Tumorales / Transcriptoma / Neoplasias Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Nat Genet Asunto de la revista: GENETICA MEDICA Año: 2020 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos