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Brainstem auditory pathway of children with acute lymphoid leukemia on chemotherapy with methotrexate.
Leite, Renata Aparecida; Vosgrau, Jéssica Sales; Cortez Neto, Leticia; Santos, Nayara Pereira; Matas, Sandro Luiz de Andrade; Odone Filho, Vicente; Matas, Carla Gentile.
Afiliación
  • Leite RA; Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
  • Vosgrau JS; Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
  • Cortez Neto L; Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
  • Santos NP; Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
  • Matas SLA; Universidade Federal de São Paulo, Setor de Medicina Laboratorial, Departamento de Medicina, São Paulo SP, Brazil.
  • Odone Filho V; Universidade de São Paulo, Faculdade de Medicina, Departamento de Pediatria, São Paulo SP, Brazil.
  • Matas CG; Universidade de São Paulo, Faculdade de Medicina, Curso de Fonoaudiologia, São Paulo SP, Brazil.
Arq Neuropsiquiatr ; 78(2): 63-69, 2020 02.
Article en En | MEDLINE | ID: mdl-32022120
OBJECTIVE: Investigate the auditory pathway in the brainstem of children with acute lymphoblastic leukemia submitted to chemotherapy (by intravenous or intrathecal infusion). METHODS: Fourteen children aged between 2 and 12 years with diagnosis of acute lymphoid leukemia were evaluated. The following procedures were used: meatoscopy, acoustic immitance measurements, tonal audiometry, vocal audiometry, transient otoacoustic emissions, and auditory brainstem response. RESULTS: From the 14 children with normal auditory thresholds, 35.71% showed an alteration in auditory brainstem response, with a predominance of hearing impairment in the lower brainstem. It was found that 80% of the children with alteration had used intrathecal methotrexate less than 30 days and that 40% had the highest cumulative intravenous methotrexate doses. CONCLUSION: Children with acute lymphoblastic leukemia submitted to chemotherapy, present auditory pathway impairment in the brainstem, with a predominance of a low brainstem.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Emisiones Otoacústicas Espontáneas / Leucemia-Linfoma Linfoblástico de Células Precursoras Límite: Child / Child, preschool / Humans Idioma: En Revista: Arq Neuropsiquiatr Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Emisiones Otoacústicas Espontáneas / Leucemia-Linfoma Linfoblástico de Células Precursoras Límite: Child / Child, preschool / Humans Idioma: En Revista: Arq Neuropsiquiatr Año: 2020 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Alemania