% RET, percent reticulocyte; 90-day subchronic study; ABAS, absolute basophil; AEOS, absolute eosinophil; ALB, albumin; ALKP, alkaline phosphatase; ALT, alanine aminotransferase; ALUC, absolute large unstained cell; ALYM, absolute lymphocyte; AMON, absolute monocyte; ANEU, absolute neutrophil; ANOVA, one-way analysis of variance; ARET, absolute reticulocyte; AST, aspartate aminotransferase; BUN, urea nitrogen; CAS, Chemical Abstracts Service; CHOL, cholesterol; CREAT, creatinine; Cellulose; DLS, dynamic light scattering; EDXS, energy-dispersive X-ray spectroscopy; EFSA, European Food Safety Authority; FDA, U.S. Food and Drug Administration; Fibrillated cellulose; GLOB, globulin; GLP, good laboratory practice; GLU, glucose; GRAS, generally recognized as safe; HBG, hemoglobin; HCT, hematocrit; MCH, mean corpuscular cell hemoglobin; MCHC, mean corpuscular cell hemoglobin concentration; MCV, mean corpuscular cell volume; NOAEL; NOAEL, no-observed-adverse-effect level; OECD 408; OECD, Organisation for Economic Co-operation and Development; Oral exposure; PLT, platelet count; RBC, red blood cell count; RDW, red cell distribution width; SCOGS, Select Committee on GRAS Substances; SDH, sorbitol dehydrogenase; SEM, scanning electron microscopy; TBA, total bile acids; TBIL, total bilirubin; TEM, transmission electron microscopy; TEMPO, 2,2,6,6-tetramethyl-piperidinyloxyl; TP, total protein; TRIG, triglycerides; WBC, white blood cell count