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Timing of postnatal steroids for bronchopulmonary dysplasia: association with pulmonary and neurodevelopmental outcomes.
Harmon, Heidi M; Jensen, Erik A; Tan, Sylvia; Chaudhary, Aasma S; Slaughter, Jonathan L; Bell, Edward F; Wyckoff, Myra H; Hensman, Angelita M; Sokol, Gregory M; DeMauro, Sara B.
Afiliación
  • Harmon HM; Department of Pediatrics, University of Iowa, Iowa City, IA, USA. heidi-harmon@uiowa.edu.
  • Jensen EA; Department of Pediatrics, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA, USA.
  • Tan S; Social, Statistical and Environmental Sciences Unit, RTI International, Washington, DC, USA.
  • Chaudhary AS; Department of Pediatrics, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA, USA.
  • Slaughter JL; Section of Neonatology, Nationwide Children's Hospital and The Ohio State University, Columbus, OH, USA.
  • Bell EF; Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
  • Wyckoff MH; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  • Hensman AM; Department of Pediatrics, Women & Infants Hospital, Brown University, Providence, RI, USA.
  • Sokol GM; Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
  • DeMauro SB; Department of Pediatrics, The Children's Hospital of Philadelphia and The University of Pennsylvania, Philadelphia, PA, USA.
J Perinatol ; 40(4): 616-627, 2020 04.
Article en En | MEDLINE | ID: mdl-32020038
OBJECTIVE: To determine the associations between age at first postnatal corticosteroids (PNS) exposure and risk for severe bronchopulmonary dysplasia (BPD) and neurodevelopmental impairment (NDI). STUDY DESIGN: Cohort study of 951 infants born <27 weeks gestational age at NICHD Neonatal Research Network sites who received PNS between 8 days of life (DOL) and 36 weeks' postmenstrual age was used to produce adjusted odds ratios (aOR). RESULTS: Compared with infants in the reference group (22-28 DOL-lowest rate), aOR for severe BPD was similar for children given PNS between DOL 8 and 49 but higher among infants treated at DOL 50-63 (aOR 1.77, 95% CI 1.03-3.06), and at DOL ≥64 (aOR 3.06, 95% CI 1.44-6.48). The aOR for NDI did not vary significantly by age of PNS exposure. CONCLUSION: For infants at high risk of BPD, initial PNS should be considered prior to 50 DOL for the lowest associated odds of severe BPD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia Broncopulmonar / Dexametasona / Recien Nacido Extremadamente Prematuro / Glucocorticoides Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Displasia Broncopulmonar / Dexametasona / Recien Nacido Extremadamente Prematuro / Glucocorticoides Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Female / Humans / Infant / Male / Newborn Idioma: En Revista: J Perinatol Asunto de la revista: PERINATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos