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Serum Anti-Müllerian Hormone in the Prediction of Response to hCG Stimulation in Children With DSD.
Lucas-Herald, Angela K; Kyriakou, Andreas; Alimussina, Malika; Guaragna-Filho, Guilherme; Diver, Louise A; McGowan, Ruth; Smith, Karen; McNeilly, Jane D; Ahmed, S Faisal.
Afiliación
  • Lucas-Herald AK; Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK.
  • Kyriakou A; British Heart Foundation Centre for Research Excellence, University of Glasgow, Glasgow, UK.
  • Alimussina M; Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK.
  • Guaragna-Filho G; Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK.
  • Diver LA; Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
  • McGowan R; West of Scotland Molecular and Clinical Genetics Service, Queen Elizabeth University Hospital, Glasgow, UK.
  • Smith K; Developmental Endocrinology Research Group, University of Glasgow, Glasgow, UK.
  • McNeilly JD; West of Scotland Molecular and Clinical Genetics Service, Queen Elizabeth University Hospital, Glasgow, UK.
  • Ahmed SF; Department of Biochemistry, Glasgow Royal Infirmary, Glasgow, UK.
J Clin Endocrinol Metab ; 105(5)2020 05 01.
Article en En | MEDLINE | ID: mdl-32016383
INTRODUCTION: The relationship between serum anti-Müllerian hormone (AMH) and the testosterone response to human chorionic gonadotropin (hCG) stimulation test is unclear. METHODS: Children who had hCG stimulation tests in one tertiary centre from 2001 to 2018 were included (n = 138). Serum testosterone was measured before (day 1 [D1]) and after 3 days (D4) of hCG stimulation. Sixty-one of these children also had prolonged hCG stimulation for 2 more weeks and serum testosterone measured after 21 days (D22). All children had a serum AMH measured on D1. RESULTS: Of the 138 children, D4 testosterone was normal in 104 (75%). AMH was low in 24/138 (17%) children, and 16 (67%) of these had a low D4 testosterone. Median AMH in those who had a normal vs low D4 testosterone was 850 pmol/L (24, 2280) and 54 pmol/L (0.4, 1664), respectively (P < 0.0001). An AMH > 5th centile was associated with a low D4 testosterone in 18/118 (13%; P < 0.0001). Of the 61 children who had prolonged hCG stimulation, D22 testosterone was normal in 39 (64%). AMH was low in 10/61(16%) children and 9 (90%) of these had a low D22 testosterone. Median AMH in children who responded and did not respond by D22 was 639 pmol/L (107, 2280) and 261 pmol/L (15, 1034) (P < 0.0001). CONCLUSION: A normal AMH may provide valuable information on overall testicular function. However, a low AMH does not necessarily predict a suboptimal testosterone response to hCG stimulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Desarrollo Sexual / Hormona Antimülleriana / Biomarcadores Farmacológicos / Gonadotropina Coriónica Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: Europa Idioma: En Revista: J Clin Endocrinol Metab Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Desarrollo Sexual / Hormona Antimülleriana / Biomarcadores Farmacológicos / Gonadotropina Coriónica Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: Europa Idioma: En Revista: J Clin Endocrinol Metab Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos