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A Pre-operative Score to Discriminate Fibroepithelial Lesions of the Breast: Phyllode Tumor or Fibroadenoma?
Mimoun, Camille; Zeller, Amelie; Seror, Julien; Majoulet, Laurene; Marchand, Eva; Mezzadri, Matthieu; Cherel, Pascal; Place, Vinciane; Cornelis, Françoise; Benifla, Jean-Louis; Rouzier, Roman.
Afiliación
  • Mimoun C; Department of Surgical Oncology, Rene Huguenin, Saint-Cloud, France mimouncamille@gmail.com.
  • Zeller A; Department of Gynecology and Obstetrics, Lariboisiere Hospital, Paris, France.
  • Seror J; Research unit EA 7285 "Risk and safety in clinical medicine for women and perinatal health", University of Versailles Saint-Quentin (UVSQ), Versailles, France.
  • Majoulet L; Department of Gynecology and Obstetrics, Lariboisiere Hospital, Paris, France.
  • Marchand E; Department of Surgical Oncology, Rene Huguenin, Saint-Cloud, France.
  • Mezzadri M; Department of Surgical Oncology, Rene Huguenin, Saint-Cloud, France.
  • Cherel P; Department of Gynecology and Obstetrics, Lariboisiere Hospital, Paris, France.
  • Place V; Department of Gynecology and Obstetrics, Lariboisiere Hospital, Paris, France.
  • Cornelis F; Department of Surgical Oncology, Rene Huguenin, Saint-Cloud, France.
  • Benifla JL; Department of Gynecology and Obstetrics, Lariboisiere Hospital, Paris, France.
  • Rouzier R; Department of Gynecology and Obstetrics, Lariboisiere Hospital, Paris, France.
Anticancer Res ; 40(2): 1095-1100, 2020 Feb.
Article en En | MEDLINE | ID: mdl-32014959
BACKGROUND/AIM: Fibroepithelial lesions (FEL) of the breast include fibroadenomas and phyllodes tumors (PT). Their histologic characteristics on core needle biopsy can overlap, while their clinical management is different. The aim of this study was to develop and to validate a pre-operative score for the diagnosis of PT with surgical decision rules. PATIENTS AND METHODS: We developed a pre-operative score for the diagnosis of PT by performing logistic regression on 217 FEL of the Rene Huguenin Hospital. This score and the surgical decision rules were validated on 87 FEL of the Lariboisiere Hospital. RESULTS: Three variables were independently and significantly associated with PT: age ≥40 years, mammography's tumor size ≥3 cm and PT diagnosed by CNB. The pre-operative score was based on these three criteria with values ranging from 0 to 10. Surgical decision rules were created: the low-risk group of PT (score≤2) had a sensitivity of 92.6% and a LR- of 0.2, the high-risk group (score>7) had a specificity of 93.5% and a LR+ of 4.4. In the validation sample, surgical decision rules were applied. CONCLUSION: These surgical decision rules may prove useful in deciding which FEL needs surgical resection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mama / Neoplasias de la Mama / Neoplasias Fibroepiteliales / Fibroadenoma / Tumor Filoide Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mama / Neoplasias de la Mama / Neoplasias Fibroepiteliales / Fibroadenoma / Tumor Filoide Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Anticancer Res Año: 2020 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Grecia