Ultrasound-triggered delivery of paclitaxel encapsulated in an emulsion at low acoustic pressures.
J Mater Chem B
; 8(8): 1640-1648, 2020 02 26.
Article
en En
| MEDLINE
| ID: mdl-32011617
We investigated the in vitro ultrasound-triggered delivery of paclitaxel, a well known anti-cancerous drug, encapsulated in an emulsion and in the presence of CT26 tumor cells. The emulsion was made of nanodroplets, whose volume comprised 95% perfluoro-octyl bromide and 5% tributyl O-acetylcitrate, in which paclitaxel was solubilized. These nanodroplets, prepared using a high-pressure microfluidizer, were stabilized by a tailor-made and recently patented biocompatible fluorinated surfactant. The delivery investigations were performed at 37 °C using a high intensity focused ultrasound transducer at a frequency of 1.1 MHz. The ultrasonic pulse was made of 275 sinusoidal periods and the pulse repetition frequency was 200 Hz with a duty cycle of 5%. The measured viabilities of CT26 cells showed that paclitaxel delivery was achievable for peak-to-peak pressures of 0.4 and 3.5 MPa, without having to vaporize the perfluorocarbon part of the droplet or to induce inertial cavitation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Paclitaxel
/
Emulsiones
/
Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Revista:
J Mater Chem B
Año:
2020
Tipo del documento:
Article
País de afiliación:
Líbano
Pais de publicación:
Reino Unido