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Temporal development of neurochemical and cognitive impairments following reserpine administration in rats.
Pereira, Aline Guimarães; Poli, Anicleto; Matheus, Filipe Carvalho; de Bortoli da Silva, Lucila; Fadanni, Guilherme Pasetto; Izídio, Geison Souza; Latini, Alexandra; Prediger, Rui Daniel.
Afiliación
  • Pereira AG; Graduate Program of Developmental and Cellular Biology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil; Graduate Program of Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Braz
  • Poli A; Graduate Program of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
  • Matheus FC; Department of Pharmaceutical Sciences, Center of Health Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
  • de Bortoli da Silva L; LABOX, Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
  • Fadanni GP; Graduate Program of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
  • Izídio GS; Graduate Program of Developmental and Cellular Biology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil; Graduate Program of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Braz
  • Latini A; LABOX, Department of Biochemistry, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
  • Prediger RD; Graduate Program of Pharmacology, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil; Graduate Program of Neuroscience, Center of Biological Sciences, Federal University of Santa Catarina, Florianópolis, SC, 88040-900, Brazil.
Behav Brain Res ; 383: 112517, 2020 04 06.
Article en En | MEDLINE | ID: mdl-32006562
The systemic administration of low reserpine (RES) doses (0.1-1.0 mg/kg) has been proposed as a valuable rat model for the study of non-motor symptoms of Parkinson's disease (PD). Here, we investigated the temporal-dependent effects of RES (1 mg/kg, s.c.) on short-term memory and locomotion, as well as, the levels of dopamine, serotonin and its metabolites in the striatum, hippocampus and prefrontal cortex at 3, 24 or 72 h after RES administration. RES administrations resulted in social and object recognition memory impairment and increased dopamine turnover in the striatum, without changes in the rat spontaneous locomotor activity, 3 h after RES administration. Altogether, these results provide new insights for the use of RES administration as an experimental design for the study of PD non-motor symptoms in rats.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Ratas / Reserpina / Inhibidores de Captación Adrenérgica / Modelos Animales de Enfermedad / Disfunción Cognitiva / Locomoción / Memoria Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Ratas / Reserpina / Inhibidores de Captación Adrenérgica / Modelos Animales de Enfermedad / Disfunción Cognitiva / Locomoción / Memoria Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Behav Brain Res Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos