Decreased expression of Rev-Erb&#945; in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erb&#945; have anti-inflammatory and neuroprotective effects in the pilocarpine model.

Yue, Jiong; He, Jiaojiang; Wei, Yujia; Shen, Kaifeng; Wu, Kefu; Yang, Xiaolin; Liu, Shiyong; Zhang, Chunqing; Yang, Hui

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model.

Yue, Jiong; He, Jiaojiang; Wei, Yujia; Shen, Kaifeng; Wu, Kefu; Yang, Xiaolin; Liu, Shiyong; Zhang, Chunqing; Yang, Hui.

Afiliación

Yue J; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China.
He J; Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
Wei Y; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China.
Shen K; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China.
Wu K; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China.
Yang X; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China.
Liu S; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China.
Zhang C; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China. cqzhang@tmmu.edu.cn.
Yang H; Department of Neurosurgery, Xinqiao Hospital, Army Medical University (Third Military Medical University), 183 Xinqiao Main Street, Shapingba District, Chongqing, 400037, China. huiyangxq@163.com.

J Neuroinflammation ; 17(1): 43, 2020 Jan 31.

Article en En | MEDLINE | ID: mdl-32005256

Asunto(s)

Antiinflamatorios/farmacología; Encefalitis/genética; Encefalitis/prevención & control; Epilepsia del Lóbulo Temporal/inducido químicamente; Epilepsia del Lóbulo Temporal/metabolismo; Fármacos Neuroprotectores; Miembro 1 del Grupo D de la Subfamilia 1 de Receptores Nucleares/biosíntesis; Pirrolidinas/farmacología; Tiofenos/farmacología; Adolescente; Adulto; Animales; Convulsivantes; Citocinas/metabolismo; Encefalitis/patología; Epilepsia del Lóbulo Temporal/patología; Regulación de la Expresión Génica; Gliosis/patología; Gliosis/prevención & control; Hipocampo/patología; Humanos; Masculino; Ratones; Ratones Endogámicos C57BL; Miembro 1 del Grupo D de la Subfamilia 1 de Receptores Nucleares/agonistas; Miembro 1 del Grupo D de la Subfamilia 1 de Receptores Nucleares/genética; Pilocarpina; Estado Epiléptico/patología; Estado Epiléptico/prevención & control; Lóbulo Temporal/patología; Adulto Joven

Palabras clave

NLRP3 inflammasome; Neuroinflammation; Neuronal apoptosis; Rev-Erbα; Temporal lobe epilepsy

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pirrolidinas / Tiofenos / Fármacos Neuroprotectores / Encefalitis / Epilepsia del Lóbulo Temporal / Miembro 1 del Grupo D de la Subfamilia 1 de Receptores Nucleares / Antiinflamatorios Tipo de estudio: Prognostic_studies Límite: Adolescent / Adult / Animals / Humans / Male Idioma: En Revista: J Neuroinflammation Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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