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Genome-wide In Vivo CNS Screening Identifies Genes that Modify CNS Neuronal Survival and mHTT Toxicity.
Wertz, Mary H; Mitchem, Mollie R; Pineda, S Sebastian; Hachigian, Lea J; Lee, Hyeseung; Lau, Vanessa; Powers, Alex; Kulicke, Ruth; Madan, Gurrein K; Colic, Medina; Therrien, Martine; Vernon, Amanda; Beja-Glasser, Victoria F; Hegde, Mudra; Gao, Fan; Kellis, Manolis; Hart, Traver; Doench, John G; Heiman, Myriam.
Afiliación
  • Wertz MH; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Mitchem MR; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Pineda SS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA; Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA 02139, USA.
  • Hachigian LJ; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Lee H; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Lau V; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Powers A; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Kulicke R; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Madan GK; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA.
  • Colic M; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Therrien M; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Vernon A; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Beja-Glasser VF; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research at MIT, Cambridge, MA 02139, USA.
  • Hegde M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Gao F; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Bioinformatics Resource Center in the Beckman Institute at Caltech, Pasadena, CA 91125, USA.
  • Kellis M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; MIT Computer Science and Artificial Intelligence Laboratory, Cambridge, MA 02139, USA.
  • Hart T; University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Heiman M; Department of Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA; Picower Institute for Learning and Memory, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. Electronic address: mheiman@mit.edu.
Neuron ; 106(1): 76-89.e8, 2020 04 08.
Article en En | MEDLINE | ID: mdl-32004439
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Supervivencia Celular / Neostriado / Enfermedad de Huntington / Proteína Huntingtina / Neuronas Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Supervivencia Celular / Neostriado / Enfermedad de Huntington / Proteína Huntingtina / Neuronas Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos