Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection.

Crown, Anthony; McAlary, Luke; Fagerli, Eric; Brown, Hilda; Yerbury, Justin J; Galaleldeen, Ahmad; Cashman, Neil R; Borchelt, David R; Ayers, Jacob I

Crown, Anthony; McAlary, Luke; Fagerli, Eric; Brown, Hilda; Yerbury, Justin J; Galaleldeen, Ahmad; Cashman, Neil R; Borchelt, David R; Ayers, Jacob I.

Afiliación

Crown A; Center for Translational Research in Neurodegenerative Disease, SantaFe HealthCare Alzheimer's Disease Research Center, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America.
McAlary L; Molecular Horizons and School of Chemistry & Molecular Bioscience, University of Wollongong, New South Wales, Australia.
Fagerli E; Illawarra Health and Medical Research Institute, School of Chemistry & Molecular Bioscience, University of Wollongong, New South Wales, Australia.
Brown H; Center for Translational Research in Neurodegenerative Disease, SantaFe HealthCare Alzheimer's Disease Research Center, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America.
Yerbury JJ; Center for Translational Research in Neurodegenerative Disease, SantaFe HealthCare Alzheimer's Disease Research Center, Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, United States of America.
Galaleldeen A; Molecular Horizons and School of Chemistry & Molecular Bioscience, University of Wollongong, New South Wales, Australia.
Cashman NR; Illawarra Health and Medical Research Institute, School of Chemistry & Molecular Bioscience, University of Wollongong, New South Wales, Australia.
Borchelt DR; Department of Biological Sciences, St. Mary's University, San Antonio, Texas, United States of America.
Ayers JI; Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia, Canada.

PLoS One ; 15(1): e0227655, 2020.

Article en En | MEDLINE | ID: mdl-31999698

Asunto(s)

Priones/química; Priones/genética; Superóxido Dismutasa-1/química; Superóxido Dismutasa-1/genética; Sustitución de Aminoácidos; Esclerosis Amiotrófica Lateral/genética; Esclerosis Amiotrófica Lateral/metabolismo; Animales; Animales Recién Nacidos; Modelos Animales de Enfermedad; Femenino; Humanos; Masculino; Ratones; Ratones Transgénicos; Mutagénesis Sitio-Dirigida; Priones/metabolismo; Agregación Patológica de Proteínas/genética; Agregación Patológica de Proteínas/metabolismo; Proteínas Recombinantes de Fusión/química; Proteínas Recombinantes de Fusión/genética; Proteínas Recombinantes de Fusión/metabolismo; Superóxido Dismutasa-1/metabolismo; Triptófano/química

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Priones / Superóxido Dismutasa-1 Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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