A fluorescent naphthalimide NADH mimic for continuous and reversible sensing of cellular redox state.

Sharma, Hemant; Tan, Nian Kee; Trinh, Natalie; Yeo, Jia Hao; New, Elizabeth J; Pfeffer, Frederick M

Sharma, Hemant; Tan, Nian Kee; Trinh, Natalie; Yeo, Jia Hao; New, Elizabeth J; Pfeffer, Frederick M.

Afiliación

Sharma H; School of Life and Environmental Sciences, Deakin University, Waurn Ponds, Victoria 3216, Australia. fred.pfeffer@deakin.edu.au.
Tan NK; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Trinh N; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Yeo JH; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
New EJ; School of Chemistry, The University of Sydney, Sydney, NSW 2006, Australia.
Pfeffer FM; School of Life and Environmental Sciences, Deakin University, Waurn Ponds, Victoria 3216, Australia. fred.pfeffer@deakin.edu.au.

Chem Commun (Camb) ; 56(15): 2240-2243, 2020 Feb 20.

Article en En | MEDLINE | ID: mdl-31998902

RESUMEN

A fluorescent, naphthalimide-based, NADH mimic has been synthesised as a reversible, biocompatible, "on-off" probe for the detection of changes in intracellular redox environment (both oxidation and reduction). Interconversion was confirmed by means of electrochemistry and also 1H NMR, UV-vis and fluorescence spectroscopy. The reversibility was also successfully detected in A549 cells under simulated redox stress.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Reino Unido

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