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Cross-talk between CD38 and TTP Is Essential for Resolution of Inflammation during Microbial Sepsis.
Joe, Yeonsoo; Chen, Yingqing; Park, Jeongmin; Kim, Hyo Jeong; Rah, So-Young; Ryu, Jinhyun; Cho, Gyeong Jae; Choi, Hye-Seon; Ryter, Stefan W; Park, Jeong Woo; Kim, Uh-Hyun; Chung, Hun Taeg.
Afiliación
  • Joe Y; School of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.
  • Chen Y; National Creative Research Laboratory for Ca(2+) signaling Network, Chonbuk National University Medical School, Jeonju 54907, Korea; Dalian University Medical College, Dalian 116622, China.
  • Park J; School of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.
  • Kim HJ; School of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.
  • Rah SY; National Creative Research Laboratory for Ca(2+) signaling Network, Chonbuk National University Medical School, Jeonju 54907, Korea.
  • Ryu J; Department of Anatomy, School of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52728, Korea.
  • Cho GJ; Department of Anatomy, School of Medicine and Institute of Health Sciences, Gyeongsang National University, Jinju 52728, Korea.
  • Choi HS; School of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.
  • Ryter SW; Joan and Sanford I. Weill Department of Medicine, Division of Pulmonary and Critical Care Medicine, Weill Cornell Medical Center, New York, NY 10065, USA.
  • Park JW; School of Biological Sciences, University of Ulsan, Ulsan 44610, Korea.
  • Kim UH; National Creative Research Laboratory for Ca(2+) signaling Network, Chonbuk National University Medical School, Jeonju 54907, Korea. Electronic address: uhkim@chonbuk.ac.kr.
  • Chung HT; School of Biological Sciences, University of Ulsan, Ulsan 44610, Korea. Electronic address: chung@ulsan.ac.kr.
Cell Rep ; 30(4): 1063-1076.e5, 2020 01 28.
Article en En | MEDLINE | ID: mdl-31995750
The resolution phase of acute inflammation is essential for tissue homeostasis, yet the underlying mechanisms remain unclear. We demonstrate that resolution of inflammation involves interactions between CD38 and tristetraprolin (TTP). During the onset of acute inflammation, CD38 levels are increased, leading to the production of Ca2+-signaling messengers, nicotinic acid adenine dinucleotide phosphate (NAADP), ADP ribose (ADPR), and cyclic ADPR (cADPR) from NAD(P)+. To initiate the onset of resolution, TTP expression is increased by the second messengers, NAADP and cADPR, which downregulate CD38 expression. The activation of TTP by Sirt1-dependent deacetylation, in response to increased NAD+ levels, suppresses the acute inflammatory response and decreases Rheb expression, inhibits mTORC1, and induces autophagolysosomes for bacterial clearance. TTP may represent a mechanistic target of anti-inflammatory agents, such as carbon monoxide. TTP mediates crosstalk between acute inflammation and autophagic clearance of bacteria from damaged tissue in the resolution of inflammation during sepsis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Sepsis / ADP-Ribosil Ciclasa 1 / Tristetraprolina / Inflamación Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicoproteínas de Membrana / Sepsis / ADP-Ribosil Ciclasa 1 / Tristetraprolina / Inflamación Tipo de estudio: Prognostic_studies Idioma: En Revista: Cell Rep Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos