18-HA, adult mice fed with 18 weeks HFD; 18-LA, adult mice fed with 18 weeks LFD; 4-HA, adult mice fed with 4 weeks HFD; 4-LA, adult mice fed with 4 weeks LFD; 7-ER, 7-ethoxyresorufin; 8-HA, adult mice fed with 8 weeks HFD; 8-LA, adult mice fed with 8 weeks LFD; AhR, aryl hydrocarbon receptor; BMI, body mass index; CAR, constitutive androstane receptor; CHZ, chlorzoxazone; CYP2E1, cytochrome P450 2E1; DIO, diet-induced obesity; DMEs, drug-metabolizing enzymes; Diet-induced obesity; Drug-metabolizing enzymes; EFV, efavirenz; Gapdh, glyceraldehyde-3-phosphate dehydrogenase; HFD, high-fat diet; HNF4α, hepatocyte nuclear factor 4 alpha; High-fat diet; LFD, low-fat diet; MDZ, midazolam; MPA, mobile phase A; MPB, mobile phase B; NADPH, nicotinamide adenine dinucleotide phosphate; NAFLD, non-alcoholic fatty liver disease; NRs, nuclear receptors; Nuclear receptors; O-18-HA, offspring from parental mice fed with 18 weeks HFD; O-18-LA, offspring from parental mice fed with 18 weeks LFD; O-4-HA, offspring from parental mice fed with 4 weeks HFD; O-4-LA, offspring from parental mice fed with 4 weeks LFD; O-8-HA, offspring from parental mice fed with 8 weeks HFD; O-8-LA, offspring from parental mice fed with 8 weeks LFD; Ontogenic expression; Overweight; PBS, phosphate-buffered saline; PPARα, peroxisome proliferator-activated receptor alpha; PXR, pregnane X receptor; RSF, resorufin; RT-qPCR, real-time quantitative PCR; SD, standard deviation; SULT1A1, sulfotransferase 1A1; UGT1A1, uridine diphosphate glucuronosyltransferase 1A1