Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids.

Wang, Siqi; Wang, Yang; Xun, Xiaodong; Zhang, Changkun; Xiang, Xiao; Cheng, Qian; Hu, Shihua; Li, Zhao; Zhu, Jiye

Wang, Siqi; Wang, Yang; Xun, Xiaodong; Zhang, Changkun; Xiang, Xiao; Cheng, Qian; Hu, Shihua; Li, Zhao; Zhu, Jiye.

Afiliación

Wang S; Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Wang Y; Beijing Key Laboratory of HCC and Liver Cirrhosis, Beijing, China.
Xun X; Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Zhang C; Beijing Key Laboratory of HCC and Liver Cirrhosis, Beijing, China.
Xiang X; Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Cheng Q; Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Hu S; Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Li Z; Department of Hepatobiliary Surgery, Peking University People's Hospital, Beijing, China.
Zhu J; Peking University Center of Liver Cancer Diagnosis and Treatment, Beijing, China.

J Exp Clin Cancer Res ; 39(1): 22, 2020 Jan 28.

Article en En | MEDLINE | ID: mdl-31992334

Asunto(s)

Antineoplásicos/uso terapéutico; Carcinoma Hepatocelular/tratamiento farmacológico; Resistencia a Antineoplásicos/efectos de los fármacos; Proteínas Hedgehog/metabolismo; Neoplasias Hepáticas/tratamiento farmacológico; Organoides/metabolismo; Sorafenib/uso terapéutico; Animales; Antineoplásicos/farmacología; Carcinoma Hepatocelular/patología; Línea Celular Tumoral; Modelos Animales de Enfermedad; Humanos; Neoplasias Hepáticas/patología; Ratones; Transducción de Señal; Sorafenib/farmacología

Palabras clave

CD44; Hedgehog signaling; Hepatocellular carcinoma; Patient-derived organoids (PDOs)

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organoides / Carcinoma Hepatocelular / Resistencia a Antineoplásicos / Proteínas Hedgehog / Sorafenib / Neoplasias Hepáticas / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: J Exp Clin Cancer Res Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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