A Cancer-Specific Ubiquitin Ligase Drives mRNA Alternative Polyadenylation by Ubiquitinating the mRNA 3' End Processing Complex.

Yang, Seung Wook; Li, Lei; Connelly, Jon P; Porter, Shaina N; Kodali, Kiran; Gan, Haiyun; Park, Jung Mi; Tacer, Klementina Fon; Tillman, Heather; Peng, Junmin; Pruett-Miller, Shondra M; Li, Wei; Potts, Patrick Ryan

Yang, Seung Wook; Li, Lei; Connelly, Jon P; Porter, Shaina N; Kodali, Kiran; Gan, Haiyun; Park, Jung Mi; Tacer, Klementina Fon; Tillman, Heather; Peng, Junmin; Pruett-Miller, Shondra M; Li, Wei; Potts, Patrick Ryan.

Afiliación

Yang SW; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li L; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Connelly JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Porter SN; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Kodali K; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Gan H; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Park JM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tacer KF; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Tillman H; Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Peng J; Departments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Li W; Department of Biological Chemistry, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA; Division of Biostatistics, Dan L. Duncan Cancer Center and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Potts PR; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: ryan.potts@stjude.org.

Mol Cell ; 77(6): 1206-1221.e7, 2020 03 19.

Article en En | MEDLINE | ID: mdl-31980388

Asunto(s)

Regiones no Traducidas 3'/genética; Antígenos de Neoplasias/metabolismo; Neoplasias Pulmonares/patología; Proteínas de Neoplasias/metabolismo; Neoplasias Ováricas/patología; ARN Mensajero/metabolismo; Ubiquitina/metabolismo; Factores de Escisión y Poliadenilación de ARNm/metabolismo; Animales; Antígenos de Neoplasias/genética; Apoptosis; Biomarcadores de Tumor; Carcinogénesis; Carcinoma de Células Escamosas/genética; Carcinoma de Células Escamosas/metabolismo; Carcinoma de Células Escamosas/patología; Proliferación Celular; Factor de Especificidad de Desdoblamiento y Poliadenilación/genética; Factor de Especificidad de Desdoblamiento y Poliadenilación/metabolismo; Femenino; Regulación Neoplásica de la Expresión Génica; Humanos; Neoplasias Pulmonares/genética; Neoplasias Pulmonares/metabolismo; Masculino; Ratones; Ratones Endogámicos NOD; Ratones SCID; Proteínas de Neoplasias/genética; Neoplasias Ováricas/genética; Neoplasias Ováricas/metabolismo; Poliadenilación; Empalme del ARN; ARN Mensajero/genética; Células Tumorales Cultivadas; Proteínas Supresoras de Tumor/genética; Proteínas Supresoras de Tumor/metabolismo; Ubiquitina-Proteína Ligasas/genética; Ubiquitina-Proteína Ligasas/metabolismo; Ubiquitinación; Ensayos Antitumor por Modelo de Xenoinjerto; Factores de Escisión y Poliadenilación de ARNm/genética

Palabras clave

3' UTR shortening; 3' end processing complex; CFIm25; HUWE1; MAGE-A11; PCF11; PTEN; alternative polyadenylation; cyclin D2; ubiquitin

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Ováricas / ARN Mensajero / Regiones no Traducidas 3' / Ubiquitina / Factores de Escisión y Poliadenilación de ARNm / Neoplasias Pulmonares / Antígenos de Neoplasias / Proteínas de Neoplasias Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google