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Prognostic value of the neutrophil/lymphocyte ratio in enteropancreatic neuroendocrine tumors.
Grenader, Tal; Pavel, Marianne E; Ruszniewski, Philippe B; Cwikla, Jaroslaw B; Phan, Alexandria T; Raderer, Markus; Sedlácková, Eva; Cadiot, Guillaume; Wolin, Edward M; Capdevila, Jaume; Wall, Lucy; Rindi, Guido; Truong Thanh, Xuan-Mai; Caplin, Martyn E.
Afiliación
  • Grenader T; Oncology Institute, Leumit Health Services, Jerusalem, Israel.
  • Pavel ME; Medizinische Klinik m. S. Hepatologie und Gastroenterologie, Charité University Medicine Berlin, Berlin, Germany.
  • Ruszniewski PB; Department of Endocrinology, Friedrich Alexander University Erlangen-Nuernberg, Erlangen, Germany.
  • Cwikla JB; Department of Gastroenterology-Pancreatology, Beaujon Hospital, Clichy, France.
  • Phan AT; Department of Radiology, University of Varmia and Masuria, Olsztyn, Poland.
  • Raderer M; Hematology, Oncology & Radiation Oncology, University of Texas Health Science Center at Tyler, Tyler, Texas, USA.
  • Sedlácková E; Department of Oncology, University Hospital, Vienna, Austria.
  • Cadiot G; Department of Oncology, First Faculty of Medicine and General Teaching Hospital, Prague, Czech Republic.
  • Wolin EM; Hepato-Gastroenterology & Digestive Cancerology, Robert-Debré Hospital, Reims, France.
  • Capdevila J; Medicine, Hematology and Medical Oncology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Wall L; Department of Medical Oncology, Vall d'Hebron University Hospital and Vall d'Hebron Institute of Oncology, Barcelona, Spain.
  • Rindi G; Edinburgh Cancer Centre, Western General Hospital, Edinburgh, UK.
  • Truong Thanh XM; Pathological Anatomy, Fondazione Policlinico Universitario A. Gemelli IRCCS - Università Cattolica del Sacro Cuore, Rome, Italy.
  • Caplin ME; Medical Affairs, Ipsen, Boulogne-Billancourt, France.
Anticancer Drugs ; 31(3): 216-222, 2020 03.
Article en En | MEDLINE | ID: mdl-31977567
Accessible prognostic tools are needed to individualize treatment of neuroendocrine tumors (NETs). Data suggest neutrophil/lymphocyte ratios (NLRs) have prognostic value in some solid tumors, including NETs. In the randomized double-blind CLARINET study (NCT00353496; EudraCT 2005-004904-35), the somatostatin analog lanreotide autogel/depot increased progression-free survival (PFS) compared with placebo in patients with inoperable or metastatic intestinal and pancreatic NETs (grades 1-2, Ki-67 < 10%). The exploratory post-hoc analyses presented here evaluated the prognostic value of NLR in the CLARINET study cohort, in the context of and independently from treatment. Kaplan-Meier PFS plots were generated for patients with available NLR data, in subgroups based on NLR values, and 24-month survival rates were calculated. P values and hazard ratios for prognostic effects were generated using Cox models. 31216222 Baseline characteristics were balanced between lanreotide autogel/depot 120 mg (n = 100) and placebo (n = 101) arms. Irrespective of treatment, raw 24-month PFS rates were comparable across subgroups based on NLR tertiles [37.3% (low), 38.8% (middle), 38.8% (high); n = 67 per group] and NLR cutoff of 4 [38.1% (NLR ≤ 4; n = 176), 40.0% (NLR > 4; n = 25)]. Furthermore, NLRs were not prognostic in Cox models, irrespective of subgroups used. The therapeutic effect of lanreotide autogel/depot 120 mg was independent of NLRs (P > 0.1). These exploratory post-hoc analyses in patients with advanced intestinal and pancreatic NETs contrast with previous data suggesting NLR has prognostic potential in NETs. This may reflect the inclusion of patients with lower-grade tumors or use of higher NLR cutoff values in the current analysis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Linfocitos / Tumores Neuroendocrinos / Neutrófilos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Drugs Asunto de la revista: ANTINEOPLASICOS Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Linfocitos / Tumores Neuroendocrinos / Neutrófilos Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Anticancer Drugs Asunto de la revista: ANTINEOPLASICOS Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido