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Immunohistochemical Assessment of the Diagnostic Utility of PD-L1 (Clone SP142) for Methotrexate-Associated Lymphoproliferative Disorders With an Emphasis of Neoplastic PD-L1 (Clone SP142)-Positive Classic Hodgkin Lymphoma Type.
Kohno, Kei; Suzuki, Yuka; Elsayed, Ahmed A; Sakakibara, Ayako; Takahara, Taishi; Satou, Akira; Kato, Seiichi; Nakamura, Shigeo; Asano, Naoko.
Afiliación
  • Kohno K; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
  • Suzuki Y; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
  • Elsayed AA; Department of Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
  • Sakakibara A; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
  • Takahara T; Department of Surgical Pathology, Aichi Medical University Hospital, Nagakute, Japan.
  • Satou A; Department of Surgical Pathology, Aichi Medical University Hospital, Nagakute, Japan.
  • Kato S; Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan.
  • Nakamura S; Department of Pathology and Laboratory Medicine, Nagoya University Hospital, Nagoya, Japan.
  • Asano N; Department of Clinical Laboratory, Nagano Prefectural Shinshu Medical Center, Nagano, Japan.
Am J Clin Pathol ; 153(5): 571-582, 2020 04 15.
Article en En | MEDLINE | ID: mdl-31977037
OBJECTIVES: We describe results of programmed death ligand 1 (PD-L1) immunohistochemical assessment in methotrexate (MTX)-associated lymphoproliferative disorders (LPDs) and highlight the characteristics of classic Hodgkin lymphoma (CHL) type MTX-LPD. METHODS: Fifty cases of MTX-LPD, including CHL type (n = 9), diffuse large B-cell lymphoma type (n = 15), and polymorphic B-cell LPD (n = 21), were investigated. RESULTS: Staining with anti-PD-L1 clone SP142 was exclusively found in CHL type (89%) but not in the others. Cases of CHL type MTX-LPD involved nodal disease and were associated with Epstein-Barr virus. They were histopathologically characterized by a vaguely nodular pattern, predominance of mononuclear cells, and strong expression of at least one pan-B-cell marker. Their clinical course was variable, with spontaneous regression in 5 patients, relapse in 2, and a fatal course in 1. CONCLUSIONS: The PD-L1 (clone SP142) workup aids the diagnostic approach to patients with MTX-LPD. CHL type MTX-LPD appears to represent a unique morphologic variant of CHL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Metotrexato / Antirreumáticos / Antígeno B7-H1 / Trastornos Linfoproliferativos Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Clin Pathol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin / Metotrexato / Antirreumáticos / Antígeno B7-H1 / Trastornos Linfoproliferativos Tipo de estudio: Diagnostic_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Am J Clin Pathol Año: 2020 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido