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An Update on the Progress of Isolation, Culture, Storage, and Clinical Application of Human Bone Marrow Mesenchymal Stem/Stromal Cells.
Chu, Dinh-Toi; Phuong, Thuy Nguyen Thi; Tien, Nguyen Le Bao; Tran, Dang Khoa; Thanh, Vo Van; Quang, Thuy Luu; Truong, Dang Tien; Pham, Van Huy; Ngoc, Vo Truong Nhu; Chu-Dinh, Thien; Kushekhar, Kushi.
Afiliación
  • Chu DT; Faculty of Biology, Hanoi National University of Education, Hanoi 100000, Vietnam.
  • Phuong TNT; School of Odonto Stomatology, Hanoi Medical University, Hanoi 100000, Vietnam.
  • Tien NLB; Department of Animal Science, College of Agriculture and Life Science, Chonnam National University, Gwangju 61186, Korea.
  • Tran DK; Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi 100000, Vietnam.
  • Thanh VV; Department of Anatomy, University of Medicine Pham Ngoc Thach, Ho Chi Minh City 700000, Vietnam.
  • Quang TL; Institute of Orthopaedics and Trauma Surgery, Viet Duc Hospital, Hanoi 100000, Vietnam.
  • Truong DT; Department of Surgery, Hanoi Medical University, Hanoi 100000, Vietnam.
  • Pham VH; Center for Anesthesia and Surgical Intensive Care, Viet Duc Hospital, Hanoi 100000, Vietnam.
  • Ngoc VTN; Vietnam Military Medical University, Hanoi 100000, Vietnam.
  • Chu-Dinh T; AI Lab, Faculty of Information Technology, Ton Duc Thang University, Ho Chi Minh City 700000, Vietnam.
  • Kushekhar K; School of Odonto Stomatology, Hanoi Medical University, Hanoi 100000, Vietnam.
Int J Mol Sci ; 21(3)2020 Jan 21.
Article en En | MEDLINE | ID: mdl-31973182
Bone marrow mesenchymal stem/stromal cells (BMSCs), which are known as multipotent cells, are widely used in the treatment of various diseases via their self-renewable, differentiation, and immunomodulatory properties. In-vitro and in-vivo studies have supported the understanding mechanisms, safety, and efficacy of BMSCs therapy in clinical applications. The number of clinical trials in phase I/II is accelerating; however, they are limited in the size of subjects, regulations, and standards for the preparation and transportation and administration of BMSCs, leading to inconsistency in the input and outcome of the therapy. Based on the International Society for Cellular Therapy guidelines, the characterization, isolation, cultivation, differentiation, and applications can be optimized and standardized, which are compliant with good manufacturing practice requirements to produce clinical-grade preparation of BMSCs. This review highlights and updates on the progress of production, as well as provides further challenges in the studies of BMSCs, for the approval of BMSCs widely in clinical application.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas de Cultivo de Célula / Células Madre Mesenquimatosas Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Técnicas de Cultivo de Célula / Células Madre Mesenquimatosas Tipo de estudio: Guideline Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Vietnam Pais de publicación: Suiza