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Dendrimeric Sulfanyl Porphyrazines: Synthesis, Physico-Chemical Characterization, and Biological Activity for Potential Applications in Photodynamic Therapy.
Mlynarczyk, Dariusz T; Lijewski, Sebastian; Falkowski, Michal; Piskorz, Jaroslaw; Szczolko, Wojciech; Sobotta, Lukasz; Stolarska, Magdalena; Popenda, Lukasz; Jurga, Stefan; Konopka, Krystyna; Düzgünes, Nejat; Mielcarek, Jadwiga; Goslinski, Tomasz.
Afiliación
  • Mlynarczyk DT; Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
  • Lijewski S; Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
  • Falkowski M; Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
  • Piskorz J; Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
  • Szczolko W; Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
  • Sobotta L; Department of Inorganic and Analytical Chemistry, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
  • Stolarska M; Department of Chemical Technology of Drugs, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780, Poznan, Poland.
  • Popenda L; Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 61-780, Poznan, Poland.
  • Jurga S; NanoBioMedical Centre, Adam Mickiewicz University in Poznan, Umultowska 85, 61-614, Poznan, Poland.
  • Konopka K; NanoBioMedical Centre, Adam Mickiewicz University in Poznan, Umultowska 85, 61-614, Poznan, Poland.
  • Düzgünes N; Faculty of Physics, Adam Mickiewicz University in Poznan, Umultowska 85, 61-614, Poznan, Poland.
  • Mielcarek J; Department of Biomedical Sciences, University of the Pacific, 155 Fifth Street, San Francisco, CA, 94103, USA.
  • Goslinski T; Department of Biomedical Sciences, University of the Pacific, 155 Fifth Street, San Francisco, CA, 94103, USA.
Chempluschem ; 81(5): 460-470, 2016 May.
Article en En | MEDLINE | ID: mdl-31968780
Sulfanyl porphyrazines substituted at their periphery with different dendrimeric moieties up to their first generation were synthesized and characterized by photochemical and biological methods. The presence of a dendrimeric periphery enhanced the spectral properties of the porphyrazines studied. The singlet-oxygen-generation quantum yield of the obtained macrocycles ranged from 0.02 to 0.20 and was strongly dependent on the symmetry of the compounds and the terminal groups of the dendritic outer shell. The in vitro biological effects of three most promising tribenzoporphyrazines were examined; the results indicated their potential as photosensitizers for photodynamic therapy (PDT) against two oral squamous cell carcinoma cell lines derived from the tongue. The highest photocytotoxicity was found for sulfanyl tribenzoporphyrazine that possessed 4-[3,5-di(hydroxymethyl)phenoxy]butyl substituents with nanomolar IC50 values at 10 and 42 nm against CAL 27 and HSC-3 cell lines, respectively.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chempluschem Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Chempluschem Año: 2016 Tipo del documento: Article País de afiliación: Polonia Pais de publicación: Alemania