Your browser doesn't support javascript.
loading
Expression of beta adrenergic receptor in oral squamous cell carcinoma and its significance to the prognosis.
Dong, Hao; Liao, Xian-Xiang; Mai, Hua-Ming; Zhou, Nuo; Wang, Dai-You; Peng, Jian-Bo; Yang, Liang-Hui.
Afiliación
  • Dong H; Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University Nanning, China.
  • Liao XX; Department of Oral and Maxillofacial Surgery, Guangxi Zhuang Autonomous Region People's Hospital Nanning, China.
  • Mai HM; Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University Nanning, China.
  • Zhou N; Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University Nanning, China.
  • Wang DY; Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University Nanning, China.
  • Peng JB; Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University Nanning, China.
  • Yang LH; Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University Nanning, China.
Int J Clin Exp Pathol ; 10(10): 10431-10440, 2017.
Article en En | MEDLINE | ID: mdl-31966380
The aim of this study was to detect the expression of ß-AR (Beta Adregenic Receptor) in Oral squamous cell carcinoma (OSCC), para-cancerous and normal oral mucosa and to investigate the relationship between the expression intensity and the characteristics and prognosis of oral cancer. 100 cases of OSCC were collected; 20 cases of paraneoplastic tissues and 10 cases of normal oral mucosa were taken as control. The expression of ß-AR was detected by immunohistochemical method and the average optical density determination using Image J software. Finally, the difference of ß-AR expression and the correlation with the clinicopathological factors were analyzed statistically. The expression of ß-AR in OSCC was higher than that in paracarcinoma and normal mucosa (P<0.01). The expression intensity of ß1, ß2-AR in preoperative lymph node metastasis group was higher than that in patients without lymph node metastasis (P<0.01). The expression intensity of ß3-AR was not related to pathological grade and tumor size (P>0.05). ß1 and ß2-AR in early stage of OSCC were higher than those in early stage (P<0.05). Lymph node metastasis, recurrence, TNM clinical stage, and the expression intensity of ß1-AR all had an effect on the cumulative survival rate. All the ß1, 2, 3-AR were expressed in OSCC. ß1 and ß2-AR were involved in lymphatic metastasis and had influence on clinical staging. Metastasis, recurrence, TNM stage and expression of ß1-AR had an effect on the cumulative survival rate of tumor. The expression of ß3-AR in OSCC was not associated with the pathological grades and tumor growth.
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Clin Exp Pathol Asunto de la revista: PATOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Int J Clin Exp Pathol Asunto de la revista: PATOLOGIA Año: 2017 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos