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M2 Macrophages Promote HCC Cells Invasion and Migration via miR-149-5p/MMP9 Signaling.
Liu, Guodong; Yin, Lei; Ouyang, Xiwu; Zeng, Ke; Xiao, Yao; Li, Yixiong.
Afiliación
  • Liu G; Department of Biliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Yin L; Department of Urology, Shanghai Tenth People's Hospital, School of Medicine in Tongji University, Shanghai, China.
  • Ouyang X; Department of Liver Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Zeng K; CITIC Xiangya Reproductive and Genetic Specialist Hospital, Changsha, 410008, China.
  • Xiao Y; Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
  • Li Y; Department of Biliary and Pancreatic Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
J Cancer ; 11(5): 1277-1287, 2020.
Article en En | MEDLINE | ID: mdl-31956374
The roles of M2 macrophages on promoting tumor progression and chemotherapy resistance have been well studied in many cancers, such as pancreatic cancer, kidney cancer and so on, but its linkage to HCC cells still remains unclear. Here we found that M2 macrophages could alter miR-149-5p to increase MMP9 expression in HCC cells and mechanism dissection revealed that miR-149-5p might directly target the 3'UTR of MMP9-mRNA to suppress its translation. The in vivo orthotopic xenografts mouse model with oemiR-149-5p also validated in vitro data. Together, these findings suggest that M2 macrophages may through altering the miR-149-5p to promote HCC progression and targeting the M2 macrophages/miR149-5P/MMP9 signaling may help in the development of the novel therapies to better suppress the HCC progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Cancer Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: J Cancer Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Australia