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Potential of coconut oil and medium chain triglycerides in the prevention and treatment of Alzheimer's disease.
Chatterjee, Pratishtha; Fernando, Malika; Fernando, Binosha; Dias, Cintia B; Shah, Tejal; Silva, Renuka; Williams, Shehan; Pedrini, Steve; Hillebrandt, Heidi; Goozee, Kathryn; Barin, Edward; Sohrabi, Hamid R; Garg, Manohar; Cunnane, Stephen; Martins, Ralph N.
Afiliación
  • Chatterjee P; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Fernando M; Department of Applied Nutrition, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Sri Lanka.
  • Fernando B; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Dias CB; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia; Nutraceuticals Research Program, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
  • Shah T; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; The Australian Alzheimer Research Foundation, Nedlands, WA, Australia.
  • Silva R; Department of Applied Nutrition, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Sri Lanka.
  • Williams S; Department of Psychiatry, Faculty of Medicine, University of Kelaniya, Sri Lanka.
  • Pedrini S; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia.
  • Hillebrandt H; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia.
  • Goozee K; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; The Cooperative Research Centre (CRC) for Mental Health, Carlton South, VIC, Australia; Clinical Research Department, Anglicar
  • Barin E; Macquarie University Hospital, Macquarie University, North Ryde, NSW, Australia.
  • Sohrabi HR; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; The Australian Alzheimer Research Foundation, Nedlands, WA, Australia.
  • Garg M; Nutraceuticals Research Program, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.
  • Cunnane S; Department of Medicine and Research Center on Aging, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
  • Martins RN; Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; The Cooperative Research Centre (CRC) for Mental Health, Carlton South, VIC, Australia; KaRa Institute of Neurological Disease
Mech Ageing Dev ; 186: 111209, 2020 03.
Article en En | MEDLINE | ID: mdl-31953123
Alzheimer's disease (AD) is the most common form of dementia. Currently, there is no effective medication for the prevention or treatment of AD. This has led to the search for alternative therapeutic strategies. Coconut oil(CO) has a unique fatty acid composition that is rich in medium chain fatty acids(MCFA), a major portion of which directly reaches the liver via the portal vein, thereby bypassing the lymphatic system. Given that brain glucose hypometabolism is a major early hallmark of AD, detectable well before the onset of symptoms, ketone bodies from MCFA metabolism can potentially serve as an alternative energy source to compensate for lack of glucose utilisation in the brain. Additionally, neuroprotective antioxidant properties of CO have been attributed to its polyphenolic content. This review discusses how the metabolism of CO and MCFA may aid in compensating the glucose hypometabolism observed in the AD brain. Furthermore, we present the current evidence of the neuroprotective properties of CO on cognition, amyloid-ß pathogenicity, inflammation and oxidative stress. The current review addresses the influence of CO/MCFA on other chronic disorders that are risk factors for AD, and addresses existing gaps in the literature regarding the use of CO/MCFA as a potential treatment for AD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Enfermedad de Alzheimer / Aceite de Coco Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Mech Ageing Dev Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Irlanda
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Encéfalo / Enfermedad de Alzheimer / Aceite de Coco Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Mech Ageing Dev Año: 2020 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Irlanda