Acute cerebellar toxicity induced by high dose of cytarabine (HiDAC): A case report.
J Oncol Pharm Pract
; 26(6): 1492-1494, 2020 Sep.
Article
en En
| MEDLINE
| ID: mdl-31948347
Cytarabine is a pyrimidine analogue that is used for the treatment of acute myeloid leukemia at different doses. Standard doses of cytarabine are used for induction therapy, while high doses are used for post-remission (consolidation) and relapsed/refractory treatment. One of the major side effects of its high doses is acute cerebellar toxicity occurring in 10 to 25% of patients. We report a case that developed this side effect after receiving two doses of high-dose cytarabine. The patient's symptoms improved after withholding the drug. Thereafter, the patient tolerated treatment continuation with lower doses.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Protocolos de Quimioterapia Combinada Antineoplásica
/
Cerebelo
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Citarabina
Límite:
Adult
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Female
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Humans
Idioma:
En
Revista:
J Oncol Pharm Pract
Asunto de la revista:
FARMACIA
Año:
2020
Tipo del documento:
Article
Pais de publicación:
Reino Unido