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Intermittent Hypoxic Conditioning Alleviates Post-Traumatic Stress Disorder-Induced Damage and Dysfunction of Rat Visceral Organs and Brain.
Manukhina, Eugenia B; Tseilikman, Vadim E; Karpenko, Marina N; Pestereva, Nina S; Tseilikman, Olga B; Komelkova, Maria V; Kondashevskaya, Marina V; Goryacheva, Anna V; Lapshin, Maxim S; Platkovskii, Pavel O; Sarapultsev, Alexey P; Alliluev, Anatoly V; Downey, H Fred.
Afiliación
  • Manukhina EB; School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.
  • Tseilikman VE; Laboratory for Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, Moscow 125315, Russia.
  • Karpenko MN; Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
  • Pestereva NS; School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.
  • Tseilikman OB; I.P. Pavlov Physiology Department, Institute of Experimental Medicine, St. Petersburg 197376, Russia.
  • Komelkova MV; I.P. Pavlov Physiology Department, Institute of Experimental Medicine, St. Petersburg 197376, Russia.
  • Kondashevskaya MV; School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.
  • Goryacheva AV; School of Basic Medicine, Chelyabinsk State University, Chelyabinsk 454001, Russia.
  • Lapshin MS; School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.
  • Platkovskii PO; Laboratory for Immunomorphology of Inflammation, Research Institute of Human Morphology, Moscow 117418, Russia.
  • Sarapultsev AP; Laboratory for Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, Moscow 125315, Russia.
  • Alliluev AV; School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.
  • Downey HF; School of Medical Biology, South Ural State University, Chelyabinsk 454080, Russia.
Int J Mol Sci ; 21(1)2020 Jan 05.
Article en En | MEDLINE | ID: mdl-31948051
Posttraumatic stress disorder (PTSD) causes mental and somatic diseases. Intermittent hypoxic conditioning (IHC) has cardio-, vaso-, and neuroprotective effects and alleviates experimental PTSD. IHC's ability to alleviate harmful PTSD effects on rat heart, liver, and brain was examined. PTSD was induced by 10-day exposure to cat urine scent (PTSD rats). Some rats were then adapted to 14-day IHC (PTSD+IHC rats), while PTSD and untreated control rats were cage rested. PTSD rats had a higher anxiety index (AI, X-maze test), than control or PTSD+IHC rats. This higher AI was associated with reduced glycogen content and histological signs of metabolic and hypoxic damage and of impaired contractility. The livers of PTSD rats had reduced glycogen content. Liver and blood alanine and aspartate aminotransferase activities of PTSD rats were significantly increased. PTSD rats had increased norepinephrine concentration and decreased monoamine oxidase A activity in cerebral cortex. The PTSD-induced elevation of carbonylated proteins and lipid peroxidation products in these organs reflects oxidative stress, a known cause of organ pathology. IHC alleviated PTSD-induced metabolic and structural injury and reduced oxidative stress. Therefore, IHC is a promising preventive treatment for PTSD-related morphological and functional damage to organs, due, in part, to IHC's reduction of oxidative stress.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Estrés Oxidativo Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos por Estrés Postraumático / Estrés Oxidativo Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza