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Characterization of Venom Components and Their Phylogenetic Properties in Some Aculeate Bumblebees and Wasps.
Yoon, Kyungjae Andrew; Kim, Kyungmun; Kim, Woo-Jin; Bang, Woo Young; Ahn, Neung-Ho; Bae, Chang-Hwan; Yeo, Joo-Hong; Lee, Si Hyeock.
Afiliación
  • Yoon KA; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.
  • Kim K; Department of Agricultural Biology, Seoul National University, Seoul 08826, Korea.
  • Kim WJ; EntoCode Co., Seoul 06028, Korea.
  • Bang WY; National Institute of Biological Resources, Environmental Research Complex, Incheon 22689, Korea.
  • Ahn NH; National Institute of Biological Resources, Environmental Research Complex, Incheon 22689, Korea.
  • Bae CH; National Institute of Biological Resources, Environmental Research Complex, Incheon 22689, Korea.
  • Yeo JH; National Institute of Biological Resources, Environmental Research Complex, Incheon 22689, Korea.
  • Lee SH; Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.
Toxins (Basel) ; 12(1)2020 01 14.
Article en En | MEDLINE | ID: mdl-31947554
: To identify and compare venom components and expression patterns, venom gland-specific transcriptome analyses were conducted for 14 Aculeate bees and wasps. TPM (transcripts per kilobase million) values were normalized using the average transcription level of a reference housekeeping gene (dimethyladenosine transferase). Orthologous venom component genes across the 14 bee and wasp species were identified, and their relative abundance in each species was determined by comparing normalized TPM values. Based on signal sequences in the transcripts, the genes of novel venom components were identified and characterized to encode potential allergens. Most of the allergens and pain-producing factors (arginine kinase, hyaluronidase, mastoparan, phospholipase A1, phospholipase A2, and venom allergen 5) showed extremely high expression levels in social wasps. Acid phosphatase, neprilysin, and tachykinin, which are known allergens and neurotoxic peptides, were found in the venom glands of solitary wasps more often than in social wasps. In the venom glands of bumblebees, few or no transcripts of major allergens or pain-producing factors were identified. Taken together, these results indicate that differential expression patterns of the venom genes in some Aculeate species imply that some wasps and bumblebee species have unique groups of highly expressed venom components. Some venom components reflected the Aculeate species phylogeny, but others did not. This unique evolution of specific venom components in different groups of some wasps and bumblebee species might have been shaped in response to both ecological and behavioral influences.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Avispas / Avispas / Venenos de Abeja / Abejas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Toxins (Basel) Año: 2020 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Venenos de Avispas / Avispas / Venenos de Abeja / Abejas Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Toxins (Basel) Año: 2020 Tipo del documento: Article Pais de publicación: Suiza