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The Effect of Nitroxyalkyl Succinimides on Activity of Cyclic Guanosine Monophosphate Phosphodiesterase.
Tat'yanenko, L V; Dobrokhotova, O V; Fadeev, M A; Eremeev, A B; Utyonishev, A N; Tkachev, V V; Goryachev, N S; Kotelnikov, A I; Fedorov, B S.
Afiliación
  • Tat'yanenko LV; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
  • Dobrokhotova OV; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
  • Fadeev MA; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
  • Eremeev AB; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
  • Utyonishev AN; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
  • Tkachev VV; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
  • Goryachev NS; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia. gor_ns@icp.ac.ru.
  • Kotelnikov AI; M. V. Lomonosov Moscow State University, Moscow, Russia. gor_ns@icp.ac.ru.
  • Fedorov BS; Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow region, Russia.
Bull Exp Biol Med ; 168(3): 330-333, 2020 Jan.
Article en En | MEDLINE | ID: mdl-31940127
The effect of N-nitroxymethyl succinimide (1), N-(2-nitroxyethyl) succinimide (2) and N-(3-nitroxypropyl) succinimide (3) on enzymatic activity of cyclic guanosine monophosphate (cGMP) phosphodiesterase was studied and crystal structure of compound (2) was determined. It was shown that all studied N-nitroxy succinimides inhibited cGMP phosphodiesterase in a concentration range of 0.1-0.001 mM. Compound (2) noncompetitively and reversibly inhibited hydrolytic function of enzyme with Ki=1.7×10-5 М. Inhibition constant for the reference compound N-(2-nitroethyl) nicotinamide (nicorandil) was 3×10-5 М.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Succinimidas / GMP Cíclico / Guanosina Monofosfato / Hidrolasas Diéster Fosfóricas Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Succinimidas / GMP Cíclico / Guanosina Monofosfato / Hidrolasas Diéster Fosfóricas Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2020 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos