Your browser doesn't support javascript.
loading
Enhanced therapeutic effect of paclitaxel with a natural polysaccharide carrier for local injection in breast cancer.
Jang, Hyeonjin; Zhi, Kangkang; Wang, Jiacheng; Zhao, Haitian; Li, Bin; Yang, Xin.
Afiliación
  • Jang H; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, No.92, West Dazhi Street, Nan Gang District, Harbin, Heilongjiang 150000, China.
  • Zhi K; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, No.92, West Dazhi Street, Nan Gang District, Harbin, Heilongjiang 150000, China.
  • Wang J; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, No.92, West Dazhi Street, Nan Gang District, Harbin, Heilongjiang 150000, China.
  • Zhao H; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, No.92, West Dazhi Street, Nan Gang District, Harbin, Heilongjiang 150000, China. Electronic address: zhaoht9999@163.com.
  • Li B; Academician Workstation, Jiangxi University of Traditional Chinese Medicine, No.818, Xingwanda Street, Wanli District, Nanchang, Jiangxi, 330004, China.
  • Yang X; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, No.92, West Dazhi Street, Nan Gang District, Harbin, Heilongjiang 150000, China. Electronic address: yangxin@hit.edu.cn.
Int J Biol Macromol ; 148: 163-172, 2020 Apr 01.
Article en En | MEDLINE | ID: mdl-31935404
The side effect and inefficiency of paclitaxel (PTX) in clinic have became the major problem in field of cancer chemotherapy. The local drug delivery constructed by injectable hydrogel has been suggested as the alternative due to its superior properties such as tumor selectivity, minimally invasive administration and sustained drug release behavior. Polysaccharides have been commonly used as a gelling agent to construct injectable hydrogel due to its wide resources, biocompatibility and bioactive functions. Here, we reported an injectable drug carrier with enhanced therapeutic effect based on Pinus koraiensis polysaccharide (PKP). The interaction, morphology and mechanical properties were studied. Interestingly, gels exhibited excellent injectable property including rapid recovery time, excellent thixotropy ability and good rheological property after injection, and these special properties make them more suitable to be constructed as an injectable drug carrier. In addition, the biocompatibility of gel was demonstrated in terms of hemolysis analysis. PTX-loaded gel showed excellent tumor inhibition effect against 4T1 and MCF-7 breast cancer cell lines in vitro, and exhibited the significant tumor growth suppression and reduced systemic toxicity in vivo. The successful construction of PTX-loaded gel demonstrates that PKP can be used as a promising carrier in local drug delivery.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Neoplasias de la Mama / Paclitaxel / Hidrogeles / Antineoplásicos Fitogénicos Límite: Female / Humans Idioma: En Revista: Int J Biol Macromol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Neoplasias de la Mama / Paclitaxel / Hidrogeles / Antineoplásicos Fitogénicos Límite: Female / Humans Idioma: En Revista: Int J Biol Macromol Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos