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Temporally restricted dopaminergic control of reward-conditioned movements.
Lee, Kwang; Claar, Leslie D; Hachisuka, Ayaka; Bakhurin, Konstantin I; Nguyen, Jacquelyn; Trott, Jeremy M; Gill, Jay L; Masmanidis, Sotiris C.
Afiliación
  • Lee K; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Claar LD; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, USA.
  • Hachisuka A; Allen Institute for Brain Science, Seattle, WA, USA.
  • Bakhurin KI; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Nguyen J; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.
  • Trott JM; Department of Psychology & Neuroscience, Duke University, Durham, NC, USA.
  • Gill JL; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA, USA.
  • Masmanidis SC; Neuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, CA, USA.
Nat Neurosci ; 23(2): 209-216, 2020 02.
Article en En | MEDLINE | ID: mdl-31932769
Midbrain dopamine (DA) neurons encode both reward- and movement-related events and are implicated in disorders of reward processing as well as movement. Consequently, disentangling the contribution of DA neurons in reinforcing versus generating movements is challenging and has led to lasting controversy. In this study, we dissociated these functions by parametrically varying the timing of optogenetic manipulations in a Pavlovian conditioning task and examining the influence on anticipatory licking before reward delivery. Inhibiting both ventral tegmental area and substantia nigra pars compacta DA neurons in the post-reward period had a significantly greater behavioral effect than inhibition in the pre-reward period of the task. Furthermore, the contribution of DA neurons to behavior decreased linearly as a function of elapsed time after reward. Together, the results indicate a temporally restricted role of DA neurons primarily related to reinforcing stimulus-reward associations and suggest that directly generating movements is a comparatively less important function.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recompensa / Mesencéfalo / Dopamina / Neuronas Dopaminérgicas / Movimiento Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Recompensa / Mesencéfalo / Dopamina / Neuronas Dopaminérgicas / Movimiento Límite: Animals Idioma: En Revista: Nat Neurosci Asunto de la revista: NEUROLOGIA Año: 2020 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos