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The entry of nanoparticles into solid tumours.
Sindhwani, Shrey; Syed, Abdullah Muhammad; Ngai, Jessica; Kingston, Benjamin R; Maiorino, Laura; Rothschild, Jeremy; MacMillan, Presley; Zhang, Yuwei; Rajesh, Netra Unni; Hoang, Tran; Wu, Jamie L Y; Wilhelm, Stefan; Zilman, Anton; Gadde, Suresh; Sulaiman, Andrew; Ouyang, Ben; Lin, Zachary; Wang, Lisheng; Egeblad, Mikala; Chan, Warren C W.
Afiliación
  • Sindhwani S; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Syed AM; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Ngai J; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Kingston BR; Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Maiorino L; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Rothschild J; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
  • MacMillan P; Watson School of Biological Sciences, Cold Spring Harbor, NY, USA.
  • Zhang Y; Department of Physics, University of Toronto, Toronto, Ontario, Canada.
  • Rajesh NU; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Hoang T; Department of Chemistry, University of Toronto, Toronto, Ontario, Canada.
  • Wu JLY; Division of Engineering Science, University of Toronto, Toronto, Ontario, Canada.
  • Wilhelm S; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Zilman A; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Gadde S; Stephenson School of Biomedical Engineering, University of Oklahoma, Norman, OK, USA.
  • Sulaiman A; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Ouyang B; Department of Physics, University of Toronto, Toronto, Ontario, Canada.
  • Lin Z; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
  • Wang L; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
  • Egeblad M; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
  • Chan WCW; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.
Nat Mater ; 19(5): 566-575, 2020 05.
Article en En | MEDLINE | ID: mdl-31932672
The concept of nanoparticle transport through gaps between endothelial cells (inter-endothelial gaps) in the tumour blood vessel is a central paradigm in cancer nanomedicine. The size of these gaps was found to be up to 2,000 nm. This justified the development of nanoparticles to treat solid tumours as their size is small enough to extravasate and access the tumour microenvironment. Here we show that these inter-endothelial gaps are not responsible for the transport of nanoparticles into solid tumours. Instead, we found that up to 97% of nanoparticles enter tumours using an active process through endothelial cells. This result is derived from analysis of four different mouse models, three different types of human tumours, mathematical simulation and modelling, and two different types of imaging techniques. These results challenge our current rationale for developing cancer nanomedicine and suggest that understanding these active pathways will unlock strategies to enhance tumour accumulation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas del Metal / Microambiente Tumoral / Oro / Modelos Biológicos / Neoplasias Experimentales Límite: Animals / Humans Idioma: En Revista: Nat Mater Asunto de la revista: CIENCIA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanopartículas del Metal / Microambiente Tumoral / Oro / Modelos Biológicos / Neoplasias Experimentales Límite: Animals / Humans Idioma: En Revista: Nat Mater Asunto de la revista: CIENCIA / QUIMICA Año: 2020 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido