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Fluorouracil neutrophil extracellular traps formation inhibited by polymer nanoparticle shielding.
Basyreva, Liliya Yu; Voinova, Ekaterina V; Gusev, Alexander A; Mikhalchik, Elena V; Kuskov, Andrey N; Goryachaya, Anastasiya V; Gusev, Sergey A; Shtilman, Mikhail I; Velonia, Kelly; Tsatsakis, Aristidis M.
Afiliación
  • Basyreva LY; Federal Research and Clinical Center for Physical-Chemical Medicine, Federal Medical-Biological Agency, Malaya Pirogovskaya str. 1a, Moscow, 119435, Russian Federation.
  • Voinova EV; Federal Research and Clinical Center for Physical-Chemical Medicine, Federal Medical-Biological Agency, Malaya Pirogovskaya str. 1a, Moscow, 119435, Russian Federation.
  • Gusev AA; Federal Research and Clinical Center for Physical-Chemical Medicine, Federal Medical-Biological Agency, Malaya Pirogovskaya str. 1a, Moscow, 119435, Russian Federation.
  • Mikhalchik EV; Federal Research and Clinical Center for Physical-Chemical Medicine, Federal Medical-Biological Agency, Malaya Pirogovskaya str. 1a, Moscow, 119435, Russian Federation.
  • Kuskov AN; Department of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Miusskaya sqr. 9, Moscow, 125047, Russian Federation.
  • Goryachaya AV; Department of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Miusskaya sqr. 9, Moscow, 125047, Russian Federation.
  • Gusev SA; Federal Research and Clinical Center for Physical-Chemical Medicine, Federal Medical-Biological Agency, Malaya Pirogovskaya str. 1a, Moscow, 119435, Russian Federation; Department of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Miusskaya sqr. 9, Moscow, 125047, Russian Fed
  • Shtilman MI; Department of Biomaterials, D. Mendeleev University of Chemical Technology of Russia, Miusskaya sqr. 9, Moscow, 125047, Russian Federation.
  • Velonia K; Department of Materials Science and Technology, School of Sciences and Engineering, University of Crete, University Campus Voutes, Heraklion Crete, 71003, Greece. Electronic address: velonia@materials.uoc.gr.
  • Tsatsakis AM; Laboratory of Toxicology, Medical School, University of Crete, Voutes, Heraklion Crete, 71003, Greece.
Mater Sci Eng C Mater Biol Appl ; 108: 110382, 2020 Mar.
Article en En | MEDLINE | ID: mdl-31924010
Venous thromboembolism is a frequent complication occurring in patients suffering from neoplastic diseases. Since neutrophil extracellular traps (NETs) play an important role both in the development of the tumor growth process and in inducing complications such as thrombosis, indubitably the investigation of the effect of antitumor drugs on the formation of neutrophil extracellular traps and on the ability of such drugs to prevent NETs contribution on carcinogenesis is of great interest. In the present work we studied the effect of 5-fluorouracil (5FU) and its shielded -by amphiphilic poly-N-vinylpyrrolidone (Amph-PVP) nanoparticles-nanoscaled polymeric form on the activation of human neutrophils under ex vivo conditions. Free 5FU at concentrations varying from 0.01 to 10 mg/ml was found to cause a significant (two to three times) and rapid (after 20 min) increase in the total amount of NETs in the blood. Importantly, when 5FU-loaded Amph-PVP nanoparticles were studied under the same conditions, the appearance of NETs in the blood was completely blocked providing strong evidence of their potential as delivery system for 5FU in antitumor therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Nanopartículas / Trampas Extracelulares / Fluorouracilo Límite: Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polímeros / Nanopartículas / Trampas Extracelulares / Fluorouracilo Límite: Humans Idioma: En Revista: Mater Sci Eng C Mater Biol Appl Año: 2020 Tipo del documento: Article Pais de publicación: Países Bajos