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Production of Abzymes in Th, CBA, and C57BL/6 Mice before and after MOG Treatment: Comparing Changes in Cell Differentiation and Proliferation.
Aulova, Kseniya S; Urusov, Andrey E; Toporkova, Ludmila B; Sedykh, Sergey E; Shevchenko, Yuliya A; Tereshchenko, Valery P; Sennikov, Sergei V; Budde, Thomas; Meuth, Sven G; Popova, Nelly A; Orlovskaya, Irina A; Nevinsky, Georgy A.
Afiliación
  • Aulova KS; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
  • Urusov AE; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
  • Toporkova LB; Institute of Clinical Immunology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Sedykh SE; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia.
  • Shevchenko YA; Institute of Clinical Immunology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Tereshchenko VP; Institute of Clinical Immunology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Sennikov SV; Institute of Clinical Immunology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Budde T; Westfälische Wilhelms-Universität, Institut für Physiologie I, Robert-Koch-Str. 27a, D-48149 Münster, Germany.
  • Meuth SG; Westfälische Wilhelms-Universität, Department of Neurology, Albert-Schweitzer-Campus 1, D-48149 Münster, Germany.
  • Popova NA; Institute Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
  • Orlovskaya IA; Novosibirsk State University, Novosibirsk, Russia.
  • Nevinsky GA; Institute of Clinical Immunology, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia.
Biomolecules ; 10(1)2019 12 28.
Article en En | MEDLINE | ID: mdl-31905713
Till yet there is no data concerning mechanisms of autoimmune diseases development. Experimental autoimmune encephalomyelitis (EAE) prone C57BL/6 (T- and B-lymphocyte response), non-autoimmune CBA, and Th mice with T cell response were immunized with myelin oligodendrocyte glycoprotein (MOG35-55) to compare different characteristics of autoimmune reaction development. Bone marrow differentiation profiles of hematopoietic stem cells (HSCs), lymphocyte proliferation in various organs associated with the production of antibodies against DNA, myelin basic protein (MBP), and MOG, as well as abzymes hydrolyzing these antigens, were analyzed before and after immunization. Profiles of HSC differentiation [BFU-E (erythroid burst-forming unit (early erythroid colonies), CFU-E (erythroid burst-forming unit (late erythroid colonies), CFU-GM (granulocytic-macrophagic colony-forming unit), and CFU-GEMM granulocytic-erythroid-megakaryocytic-macrophagic colony-forming unit] and patterns of lymphocyte proliferation in different organs (brain, spleen, thymus, and lymph nodes) were very different for C57BL/6, CBA, and Th mice. We conclude that only C57BL/6 mice were predisposed to spontaneous and MOG-induced acceleration of EAE development. CBA mice are not prone to the development of autoimmune reactions. After immunization, Th mice demonstrate changes in several parameters similar to C57BL/6 and other to CBA mice; Th mice are more prone to developing autoimmune reactions than CBA mice. Our data may be important for understanding the combined presence in mice lymphocytes with T and B cell responses for spontaneous and induced autoimmune diseases.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Encefalomielitis Autoinmune Experimental / Glicoproteína Mielina-Oligodendrócito Límite: Animals Idioma: En Revista: Biomolecules Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diferenciación Celular / Encefalomielitis Autoinmune Experimental / Glicoproteína Mielina-Oligodendrócito Límite: Animals Idioma: En Revista: Biomolecules Año: 2019 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza