Your browser doesn't support javascript.
loading
Self-assembled biomimetic Nano-Matrix for stem cell anchorage.
Zhou, Libo; Yau, Anne; Yu, Hongchuan; Kuhn, Liisa; Guo, Wei; Chen, Yupeng.
Afiliación
  • Zhou L; Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut.
  • Yau A; Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut.
  • Yu H; Brown University Medical School, Providence, Rhode Island.
  • Kuhn L; Brown University Medical School, Providence, Rhode Island.
  • Guo W; Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut.
  • Chen Y; Department of Biomedical Engineering, University of Connecticut, Farmington, Connecticut.
J Biomed Mater Res A ; 108(4): 984-991, 2020 04.
Article en En | MEDLINE | ID: mdl-31904174
Mesenchymal stem cells (MSCs) have been widely applied in biomedicine due to their ability to differentiate into many different cell types and their ability to synthesize a broad spectrum of growth factors and cytokines that directly and indirectly influence other cells in their vicinity. To guide MSC infiltration to a bone fracture site, we developed a novel self-assembled Nano-Matrix which can be used as an injectable scaffold to repair bone fractures. The Nano-Matrix is formed by Janus base nanotubes (JBNTs) and fibronectin (FN). JBNTs are nucleobase-derived nanotubes mimicking collagen fibers, and FN is one of the cell adhesive glycoproteins which is responsible for cell-extracellular matrix interactions and guides stem cell migration and differentiation to desired cells types. Here, we demonstrated the successful fabrication and characterization of the JBNT/FN Nano-Matrix as well as its excellent bioactivity that encouraged human MSC migration and adhesion. This work lays a solid foundation for using the Nano-Matrix as an injectable approach to improve MSC retention and function during bone fracture healing.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biomiméticos / Nanopartículas / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: J Biomed Mater Res A Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Materiales Biomiméticos / Nanopartículas / Células Madre Mesenquimatosas Límite: Humans Idioma: En Revista: J Biomed Mater Res A Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2020 Tipo del documento: Article Pais de publicación: Estados Unidos